A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling
It is identified that circPPP1R12A-73aa promoted the tumor pathogenesis and metastasis of CC via activating Hippo-YAP signaling pathway and the YAP specific inhibitor Peptide 17 dramatically alleviated the promotive effect of circPPp1R 12A- 73aa on CC cells.
MicroRNA expression profile in Treg cells in the course of primary immune thrombocytopenia
- Yuandong Zhu, Huan J. Zhu, Xiao-bao Xie, Zhuojun Zheng, Y. Ling
- BiologyJournal of Investigative Medicine
- 3 July 2019
Compared with the healthy controls, miRNAs expressed differentially in the Tregs of patients with ITP, and the levels of expression of miR-155–5p,MiR-146b- 5p, and mi-142–3p were significantly decreased, indicating that the deregulation of mi RNAs may affect the function of TregS in the course of ITP.
MicroRNA profiling of serum exosomes in patients with osteosarcoma by high-throughput sequencing
Overall, the present study identified exosomal miRNAs with dysregulated expression in patients with osteosarcoma, and they may have potential as targets for the treatment of patients with fractures.
The LncRNA XIRP2-AS1 predicts favorable prognosis in colon cancer
Clinical sample analysis showed that XIRP2-AS1 had a favorable impact on the overall survival and progression free survival of patients with colon cancer, suggesting that XirP2 -AS1 may act as a favorable biomarker for patients with Colon cancer.
Prognostic factors and outcomes of primary transitional cell carcinoma of the ureter: a population-based study
Durable cancer control can be expected in patients treated with surgery for early stage UTUC in patients diagnosed for primary transitional cell carcinoma of the ureter between 2004 and 2013.
Emerging immune checkpoints for cancer therapy
The application of LAG-3 or TIM-3 does play an important role in anti-tumor responses, and maybe better when combing with anti-CTLA-4 and anti-PD-1/L1 antibodies, and may be used in future clinical practice of cancer therapy.
Functional Implication of Exosomal miR-217 and miR-23b-3p in the Progression of Prostate Cancer
- Cuixing Zhou, Yimeng Chen, Xiaozhou He, Zhuojun Zheng, D. Xue
- BiologyOncoTargets and Therapy
- 1 November 2020
This study identified the dysregulated expression of exosomal miRNAs in PCa patients by validating their function on proliferation and invasion inPCa cells, suggesting that they can be used as potential targets in the diagnosis and treatment of PCa.
miR-183-5p Inhibits Occurrence and Progression of Acute Myeloid Leukemia via Targeting Erbin
Lower Bmi-1 Expression May Predict Longer Survival of Colon Cancer Patients
- Xiaodong Li, Xiao Zheng, Changping Wu
- Medicine, BiologyCellular Physiology and Biochemistry
- 1 November 2016
Bmi-1 expression in CC tissue is significantly higher than that in corresponding normal tissue, and while there may be a trend towards improved survival, this is not statistically significant.
B7-H3 Overexpression Predicts Poor Survival of Cancer Patients: A Meta-Analysis
This meta-analysis clarifies that elevated B7-H3 expression is significantly associated with poor survival in cancer patients and predicts a significantly poor RFS.