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TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway
The canonical transient receptor potential channels (TRPCs) are Ca2+-permeable nonselective cation channels with various physiological functions. Here, we report that TRPC6, a member of the TRPCExpand
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TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production
Generation of β-amyloid (Aβ) peptide in Alzheimer's disease involves cleavage of amyloid precursor protein (APP) by γ-secretase, a protease known to cleave several substrates, including Notch.Expand
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Targeting TRPC6 channels in oesophageal carcinoma growth
Importance of the field: Oesophageal carcinoma ranks among the ten most frequent cancers worldwide. The special growing site and malignant nature make it difficult to be completely treated byExpand
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TRPC5 Channel Is the Mediator of Neurotrophin-3 in Regulating Dendritic Growth via CaMKIIα in Rat Hippocampal Neurons
Neurotrophin-3 (NT-3) plays numerous important roles in the CNS and the elevation of intracellular Ca2+ ([Ca2+]i) is critical for these functions of NT-3. However, the mechanism by which NT-3 inducesExpand
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Ca2+ signaling initiated by canonical transient receptor potential channels in dendritic development
The spatial patterns of dendritic structures diverge in different types of neurons as adaptations to their unique functions. Although different intracellular mechanisms underlying dendriticExpand
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  • Open Access
Insoluble Tau From Human FTDP-17 Cases Exhibit Unique Transmission Properties In Vivo.
One hallmark of neurodegenerative diseases is the intracellular accumulation of hyperphosphorylated tau protein, a neuronal microtubule-associated protein, into structures known as neurofibrillaryExpand
Modulating TRADD to restore cellular homeostasis and inhibit apoptosis
Cell death in human diseases is often a consequence of disrupted cellular homeostasis. If cell death is prevented without restoring cellular homeostasis, it may lead to a persistent dysfunctional andExpand