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The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A.
- Zhuo-shen Zhao, J. P. Lim, Yuen-Wai Ng, L. Lim, E. Manser
- Biology, Medicine
- Molecular cell
- 28 October 2005
Previously, we showed PAK-PIX-GIT targets and regulates focal adhesions; here, we uncover a different function for the complex at the centrosome. Active PAK1 is particularly evident in mitosis and… Expand
DAAM1 Is a Formin Required for Centrosome Re-Orientation during Cell Migration
Background Disheveled-associated activator of morphogenesis 1 (DAAM1) is a formin acting downstream of Wnt signaling that is important for planar cell polarity. It has been shown to promote proper… Expand
A functional requirement for PAK1 binding to the KH(2) domain of the fragile X protein-related FXR1.
Loss of fragile X mental retardation protein FMR1 is the most common genetic cause of mental deficiency in man. We find that both FMR1 and the related FXR1 serve as direct binding partners for the… Expand