• Publications
  • Influence
The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A.
Previously, we showed PAK-PIX-GIT targets and regulates focal adhesions; here, we uncover a different function for the complex at the centrosome. Active PAK1 is particularly evident in mitosis andExpand
  • 221
  • 22
  • PDF
DAAM1 Is a Formin Required for Centrosome Re-Orientation during Cell Migration
Background Disheveled-associated activator of morphogenesis 1 (DAAM1) is a formin acting downstream of Wnt signaling that is important for planar cell polarity. It has been shown to promote properExpand
  • 55
  • 2
  • PDF
A functional requirement for PAK1 binding to the KH(2) domain of the fragile X protein-related FXR1.
Loss of fragile X mental retardation protein FMR1 is the most common genetic cause of mental deficiency in man. We find that both FMR1 and the related FXR1 serve as direct binding partners for theExpand
  • 39
  • 2
The Prototype Rho-Associated Kinase PAK
p21-activated kinase (PAK) was the first identified serine/threonine protein kinase to bind and be activated by Rho GTPases. Since it was discovered some 10 years ago, PAK has been intensivelyExpand