Zhuming Lam

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The human monoclonal autoantibody HF2-1/17, produced by a human-human hybridoma derived from lymphocytes of a lupus patient with thrombocytopenia, reacts with single stranded DNA and platelets. To determine the chemical nature of the autoantigen against which this antibody is directed on platelets, this platelet antigen was purified by the lipid extraction(More)
Ataxia telangiectasia (A-T) is a rare recessively inherited disorder resulting in a progressive neurological decline. It is caused by biallelic mutation of the ATM gene that encodes a 370 kDa serine/threonine protein kinase responsible for phosphorylating many target proteins. ATM is activated by auto(trans)phosphorylation in response to DNA double strand(More)
The vitamin K dependent carboxylase of liver microsomes is involved in the posttranslational modification of certain serine protease zymogens which are critical components of the blood clotting cascade. During coupled carboxylation/oxygenation this carboxylase converts glutamate residues, dihydrovitamin K, CO2, and O2 to a gamma-carboxyglutamyl (Gla)(More)
The capsular polysaccharide of Klebsiella SK1 was investigated by methylation analysis, Smith degradation, and 1H NMR spectroscopy. The oligosaccharides (P1 and P2) obtained by bacteriophage phi SK1 degradation of the polymer were studied by methylation analysis, and 1D- and 2D-NMR spectroscopy. The resulting data showed that the parent repeating unit is a(More)
This paper describes a method using L-systems that models tree growth based on the interaction of the tree's internal attributes with themselves and with environmental conditions. Modeled components include chemical flow and water distribution within the tree, phototropism, space tropism, energy generation and usage, weight support, and self-pruning.Our(More)
The Lindenmayer system (L-system) is a popular technique used in the modeling of plants. Common implementations of L-systems incorporate the definition of tree structure into production rules based on observational biological data. These system produces realistic plants, however a changing environment has no affect on results. This paper proposes animating(More)