Zhuang Jian

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The non-linear dynamic specificity of the firing pattern discharged from neurons of the internal globus pallidus (GPi) was investigated by recording their spontaneous firing using a microelectrode during posteroventral pallidotomy in eight patients with Parkinson's disease. Raw data from the cells were processed to extract spiking events (discharges above a(More)
Genetic algorithm (GA) is very helpful when the developer does not have precise domain expertise, because GA possesses the ability to explore and learn from their domain. At present, the research of GA mainly focuses on the three operators and devotes to improve the algorithm efficiency and avoid premature convergence. This paper presents a cycle mutation(More)
This publication was prepared by staff and consultants of the Asian Development Bank. The analyses, perspectives and judgments in this book do not necessarily reflect the views and policies of the Asian Development Bank, or its Board of Directors, or the governments they represent. The Asian Development Bank does not guarantee the accuracy of the data(More)
Hypoxia-inducible factor 1α (Hif1α) is a key regulator of cellular adaptation and survival under hypoxic conditions. In pancreatic ductal adenocarcinoma (PDAC), it has been recently shown that genetic ablation of Hif1α accelerates tumour development by promoting tumour-supportive inflammation in mice, questioning its role as the key downstream target of(More)
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