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Alzheimer's disease (AD) involves several possible molecular mechanisms, including impaired brain insulin signaling and glucose metabolism. To investigate the role of metabolic insults in AD, we injected streptozotocin (STZ), a diabetogenic compound if used in the periphery, into the lateral ventricle of the 6-month-old 3xTg-AD mice and studied the(More)
Alzheimer's disease (AD) can be divided into sporadic AD (SAD) and familial AD (FAD). Most AD cases are sporadic and may result from multiple etiologic factors, including environmental, genetic and metabolic factors, whereas FAD is caused by mutations of presenilins or amyloid-β (Aβ) precursor protein (APP). A commonly used mouse model for AD is 3xTg-AD(More)
Accurate traffic flow forecasting is key to the development of intelligent transportation systems (ITS). The support vector regression (SVR) method is employed for traffic flow forecasting and the comparative results between SVR and BP model using real traffic data of SCOOT system in Dalian city is also presented in this paper. Since support vector machines(More)
It is an important task to improve performance for sparse matrix vector multiplication (SpMV), and it is a difficult task because of its irregular memory access. General purpose GPU (GPGPU) provides high computing ability and substantial bandwidth that cannot be fully exploited by SpMV due to its irregularity. In this paper, we propose two novel methods to(More)
Reducing training time for artificial neural network (ANN) when training large samples is an active area of research. CThe back propagation (BP) is wildly used in Short-term Traffic Flow Forecasting Cwhich requires the training set size be much larger than the network size.C In order to improve training speed, Data parallelism is a good idea. A novel data(More)
Although acute mountain sickness (AMS) has long been recognized, little is known about this condition to date. The current study was conducted to explore changes in the metabolomic profiles of AMS patients and to further assess the potential of using these changes for the diagnosis of AMS. Plasma samples from 12 patients with AMS and 12 individuals without(More)
In vitro studies have shown that estrogen receptor β can attenuate the cytotoxic effect of amyloid β protein on PC12 cells through the Akt pathway without estrogen stimulation. In this study, we aimed to observe the effect of estrogen receptor β in Alzheimer's disease rat models established by intraventricular injection of amyloid β protein. Estrogen(More)
To design a specific polyclonal antibody against Deinagkistrodon acutus venom (DA-pAb) by immunizating New Zealand white rabbits. The IgG fraction was purified by affinity chromatography, and specific antibodies were purified by immunoaffinity chromatography. Polyclonal antibodies were subjected to ELISA and western blotting to evaluate their immune(More)
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