Zhou Songyang

Sort by:

SH2 domains recognize specific phosphopeptide sequences

Zhou Songyang, Steven E. Shoelson, +7 authors Robert J. Lechleider
Cell
1993

A phosphopeptide library was used to determine the sequence specificity of the peptide-binding sites of SH2 domains. One group of SH2 domains (Src, Fyn, Lck, Fgr, Abl, Crk, and Nck) preferred… (More)

Recognition of unique carboxyl-terminal motifs by distinct PDZ domains.

Zhou Songyang, Alan S. Fanning, +7 authors Lewis C. Cantley
Science
1997

The oriented peptide library technique was used to investigate the peptide-binding specificities of nine PDZ domains. Each PDZ domain selected peptides with hydrophobic residues at the carboxyl… (More)

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

Zhou Songyang, Kermit L. Carraway, +11 authors Lewis C. Cantley
Nature
1995

HOW do distinct protein-tyrosine kinases activate specific downstream events? Src-homology-2 (SH2) domains on tyrosine kinases or targets of tyrosine kinases recognize phosphotyrosine in a specific… (More)

SRPK2: A Differentially Expressed SR Protein-specific Kinase Involved in Mediating the Interaction and Localization of Pre-mRNA Splicing Factors in Mammalian Cells

P. H. Helen H. Wang, Wen Peng Lin, +4 authors Xiang-Dong Fu
The Journal of cell biology
1998

Reversible phosphorylation plays an important role in pre-mRNA splicing in mammalian cells. Two kinases, SR protein-specific kinase (SRPK1) and Clk/Sty, have been shown to phosphorylate the SR family… (More)

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.

Zhou Songyang, Steven E. Shoelson, +7 authors Taolin Yi
Molecular and cellular biology
1994

Src homology 2 (SH2) domains provide specificity to intracellular signaling by binding to specific phosphotyrosine (phospho-Tyr)-containing sequences. We recently developed a technique using a… (More)

Determination of the specific substrate sequence motifs of protein kinase C isozymes.

Kiyotaka Nishikawa, A. C. Toker, F J Johannes, Zhou Songyang, Lewis C. Cantley
The Journal of biological chemistry
1997

Protein kinase C (PKC) family members play significant roles in a variety of intracellular signal transduction processes, but information about the substrate specificities of each PKC family member… (More)

Use of an oriented peptide library to determine the optimal substrates of protein kinases

Zhou Songyang, Steven Blechner, Nicole Hoagland, Merl F. Hoekstra, Helen Piwnica-Worms, Lewis C. Cantley
Current Biology
1994

BACKGROUND Phosphorylation by protein kinases is an important general mechanism for controlling intracellular processes, and plays an essential part in the signal transduction pathways that regulate… (More)

Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells.

Sacha J. Holland, Nicholas Gale, +6 authors Tony J. Pawson
The EMBO journal
1997

Eph-related receptor tyrosine kinases have been implicated in the control of axonal navigation and fasciculation. To investigate the biochemical mechanisms underlying such functions, we have… (More)

A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5,…

Zhou Songyang, Kun Lu, +12 authors Lewis C. Cantley
Molecular and cellular biology
1996

We have developed a method to study the primary sequence specificities of protein kinases by using an oriented degenerate peptide library. We report here the substrate specificities of eight protein… (More)

Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts.

Raymond B Birge, J. Eduardo Fajardo, +4 authors Hidesaburo Hanafusa
Molecular and cellular biology
1993

The genome of avian sarcoma virus CT10 encodes a fusion protein in which viral Gag sequences are fused to cellular Crk sequences containing primarily Src homology 2 (SH2) and Src homology 3 (SH3)… (More)

Filter Results:

Publication Year

Publication Type

Co-author

Journals and Conferences