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The relationship between epidermal growth factor receptor (EGFR) mutation status and EGFR-tyrosine kinase inhibitors (TKI) efficacy in non-small cell lung cancer (NSCLC) patients has been well established. However, there is no available standard to define the optimal testing method and specimen type required for the detection of EGFR mutations. In this(More)
Chlamydia are obligate intracellular bacteria that frequently cause human disease. Host cells infected with Chlamydia are profoundly resistant to diverse apoptotic stimuli. The inhibition of apoptosis is thought to be an important immune escape mechanism allowing Chlamydia to productively complete their obligate intracellular growth cycle. Chlamydial(More)
Hypoxia-inducible factor 1 alpha (HIF-1a), the upstream regulator of Vascular endothelial growth factor (VEGF), is the vital hypoxia related gene expression control factor. To evaluate HIF-1a therapeutic efficacy to acute myocardial infarction, the HIF-1a expressing recombinant Adeno-associated virus (rAAV) was constructed. The Wistar rat ischemic heart(More)
Oxidation leaching copper from metal powders of waste printed circuit boards (PCBs) was conducted at room temperature in sulfuric acid solution. The result showed that the copper in metal powders was oxidized by Cu(2+) to form CuCl(2)(-) in the presence of chloride ion without electrochemical oxidation. Then, CuCl(2)(-) was oxidized into CuSO(4) by oxygen(More)
Inverse Heat Conduction Problem (IHCP) has the characteristics of non-linearity, ill-posed ness and heavy computation, because of which, there haven't been any theories or algorithms with broad application scope to solve it yet. In this paper, we use standard Particle Swarm Optimization (PSO) algorithm to solve fine-mesh 2 Dimensions (2D) IHCP. The(More)
Experiments were conducted to compare the food intake suppressant effects of the 5-hydroxytryptamine (5-HT)1 agonists 1-3-trifluoromethylphenylpiperazine hydrochloride (TFMPP) and 5-methoxy-3-(1,2,3,6-tetrahydropyridinyl)1H indole (RU 24969) following either peripheral or medial hypothalamic injections. The effects of these manipulations were examined in 3(More)
Tumstatin is a candidate tumor suppressor that plays an important role in tumor growth and angiogenesis. The purpose of this study was to evaluate the correlation between tumstatin-mRNA expression and the clinicopathologic characteristics, tumor angiogenesis, outcome of patients with non-small cell lung cancer (NSCLC). Specimens from 68 patients with NSCLC(More)
This paper analyzes the Quality of Service (QoS) requirements of Internet of Things (IOT). Combined with the QoS technology of the composite service, the author provides a decomposition and optimization method for the quality of the Internet of Things, and puts forward four basic QoS calculation methods. Also, the issue of QoS strategy management is(More)
This paper puts forward a general middleware framework of the Internet of Things (IOT). This framework has distributed, loosely coupled, scalable features. To solve the problems of machine processing of messages of IOT, the concept of ontology is introduced. The proposed algorithm can quickly classification and annotation of user demand, web services and(More)
Multifunctionality is gaining more and more importance in the field of improved biomaterials. Especially peptides feature a broad chemical variability and are versatile mediators between inorganic surfaces and living cells. Here, we synthesized a unique peptide that binds to SiO(2) with nM affinity. We equipped the peptide with the bioactive integrin(More)