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TALEN-mediated precise genome modification by homologous recombination in zebrafish
We report gene targeting via homologous recombination in zebrafish. We co-injected fertilized eggs with transcription activator–like effector nuclease mRNAs and a donor vector with long homologousExpand
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Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish
Customized TALENs and Cas9/gRNAs have been used for targeted mutagenesis in zebrafish to induce indels into protein-coding genes. However, indels are usually not sufficient to disrupt the function ofExpand
  • 334
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  • Open Access
Exosomes from Drug-Resistant Breast Cancer Cells Transmit Chemoresistance by a Horizontal Transfer of MicroRNAs
Adriamycin and docetaxel are two agents commonly used in treatment of breast cancer, but their efficacy is often limited by the emergence of chemoresistance. Recent studies indicate that exosomes actExpand
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  • Open Access
Precipitation of heavy metals from wastewater using simulated flue gas: sequent additions of fly ash, lime and carbon dioxide.
Lime is a preferred precipitant for the removal of heavy metals from industrial wastewater due to its relatively low cost. To reduce heavy metal concentration to an acceptable level for discharge, inExpand
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Two new chromone glycosides from Drynaria fortunei.
Two new chromone glycosides, drynachromoside A (1), drynachromoside B (2), along with three known flavanones, 5,7,3',5'-tetrahydroxy-flavanone (3),Expand
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Isoindolones from Lasiosphaera fenzlii Reich. and Their Bioactivities
Two new, 1 and 2, along with one known isoindolone, 3, were isolated from the AcOEt extract of Lasiosphaera fenzlii Reich. The structures of these compounds were determined asExpand
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MicroRNAs delivered by extracellular vesicles: an emerging resistance mechanism for breast cancer
Resistance to chemotherapy and endocrine therapy as well as targeted drugs is a major problem in treatment of breast cancer. Over the last decades, emerging studies have revealed that extracellularExpand
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Effects of antioxidants of bamboo leaves and flavonoids on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) formation in chemical model systems.
The inhibitory effects of antioxidants of bamboo leaves (AOB) and flavonoids against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) formation were investigated in creatinine and phenylalanineExpand
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FOXA1: a promising prognostic marker in breast cancer.
Accurate diagnosis and proper monitoring of cancer patients remain important obstacles for successful cancer treatment. The search for cancer biomarkers can aid in more accurate prediction ofExpand
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Current progress in the treatment of metaplastic breast carcinoma.
  • Q. Hu, W. Chen, +4 authors J. Zhao
  • Medicine
  • Asian Pacific journal of cancer prevention…
  • 30 November 2013
Metaplastic breast cancer (MBC) is a rare type of breast carcinoma, characterized by various combinations of mesenchymal, adenocarcinoma and other epithelial components. MBC often manifests as aExpand
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  • Open Access