Zhongyuan Chen

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Petrological, fauna] and floral infomiation derived from a new drill core taken in the Yangtze delta, coupled with data from borings recovered earlier, record a marked transition to wanner, wetter conditions which resulted in widespread inundation of the delta about 4000 years ago. Also identified for that time on the delta plain is a m;\jor discontinuity(More)
Bone metastases remain a serious health concern because of limited therapeutic options. Here, we report that crosstalk between ROR1–HER3 and the Hippo–YAP pathway promotes breast cancer bone metastasis in a long noncoding RNA-dependent fashion. Mechanistically, the orphan receptor tyrosine kinase ROR1 phosphorylates HER3 at a previously unidentified site(More)
Purpose: Recent studies show that colorectal tumors with high microsatellite instability (MSI-H) have increased immunogenicity and response to immunotherapy compared with microsatellite-stable (MSS) tumors. It is not yet clear whether MSI-H endometrial cancer may also benefit from these therapies. It is also unknown whether immune response is equivalent in(More)
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