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The ABC transporter gene family of Caenorhabditis elegans has implications for the evolutionary dynamics of multidrug resistance in eukaryotes
ABC transporter evolution fits a pattern expected from a process termed 'dynamic-coherence', which may result from the broad substrate specificity of some ABC proteins, which both reduces selection against gene loss and leads to the facile sorting of functions among paralogs following gene duplication. Expand
Multidimensional regulation of gene expression in the C. elegans embryo.
This work quantitatively measured reporter expression of 127 genes, primarily transcription factors, in every cell and with high temporal resolution in C. elegans embryos, providing the first large-scale, digitally based, cellular resolution compendium of gene expression dynamics in live animals. Expand
Expression analysis of ABC transporters reveals differential functions of tandemly duplicated genes in Caenorhabditis elegans.
The results suggest that an internal promoter can cause differential expression of genes within an operon, and suggest that it is possible for coding sequences to function as a regulatory region for a neighbouring gene. Expand
Comparative Genomics and Adaptive Selection of the ATP-Binding-Cassette Gene Family in Caenorhabditis Species
A comparative analysis of the ABC family among the three nematode species C. elegans, C. briggsae, and C. remanei found the majority of ABC genes in the three species were found in orthologous trios, indicating that the gene duplication took place before speciation. Expand
Automated analysis of embryonic gene expression with cellular resolution in C. elegans
We describe a system that permits the automated analysis of reporter gene expression in Caenorhabditis elegans with cellular resolution continuously during embryogenesis. We demonstrate its utilityExpand
Identification of a nematode chemosensory gene family.
The srab family is similar to, but distinct from, the previously described serpentine receptor class a (sra) family and shows a differential expansion in C. elegans relative to C. briggsae, suggesting that they may play a role in integrating chemosensory inputs from both ends of the organism. Expand
A Negative Regulatory Loop between MicroRNA and Hox Gene Controls Posterior Identities in Caenorhabditis elegans
How the analysis of the expression patterns of a well-conserved miRNA gene, mir-57, at cellular resolution for every minute during early development of Caenorhabditis elegans provided key insights in understanding its function is described. Expand
Control of cell cycle timing during C. elegans embryogenesis.
The results suggest a three-tier model for fate control of cell cycle pace: the primary control ofcell cycle pace is established by lineage and the founder cell fate, then fine-tuned by tissue and organ differentiation within each lineage, then further modified by individualization of cells as they acquire unique morphological and physiological roles in the variant body plan. Expand
Distinct Regulatory Elements Mediate Similar Expression Patterns in the Excretory Cell of Caenorhabditis elegans*
The results indicate that distinct regulatory elements are able to mediate the similar expression patterns in the excretory cell of Caenorhabditis elegans using a yeast one-hybrid screen. Expand
Comparative analysis of embryonic cell lineage between Caenorhabditis briggsae and Caenorhabditis elegans.
The extensive conservation of embryonic development between such divergent species suggests that substantial evolutionary distance between these two species has not altered these early developmental cellular events, although the developmental defects of transpecies hybrids suggest that the details of the underlying molecular pathways have diverged sufficiently so as to not be interchangeable. Expand