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The prostate specific membrane antigen (PSMA) is broadly overexpressed on prostate cancer (PCa) cell surfaces. In this study, we report the synthesis, characterization, in vitro binding assay, and in vivo magnetic resonance imaging (MRI) evaluation of PSMA targeting superparamagnetic iron oxide nanoparticles (SPIONs). PSMA-targeting polypeptide CQKHHNYLC(More)
Recent advances in genomics have underscored the surprising ubiquity of DNA copy number variation (CNV). Fortunately, modern genotyping platforms also detect CNVs with fairly high reliability. Hidden Markov models and algorithms have played a dominant role in the interpretation of CNV data. Here we explore CNV reconstruction via estimation with a(More)
Variations in DNA copy number carry information on the modalities of genome evolution and mis-regulation of DNA replication in cancer cells. Their study can help localize tumor suppressor genes, distinguish different populations of cancerous cells, and identify genomic variations responsible for disease phenotypes. A number of different high throughput(More)
Databases Abstract In this paper, we propose to use statistical methods to estimate unknown attribute values in databases, as compared to assigning possible values at users' discretion in common practice. Regression models and classification analysis are introduced for estimating continuous and categorical unknown attribute values, respectively. Procedures(More)
We consider a random walk on a random graph (V, E), where V is the set of open sites under i.i.d. Bernoulli site percolation on the d-dimensional integer set Z d with d ≥ 2, and the transition probabilities of the walk are generated by i.i.d. random conductances (positive numbers) assigned to the edges in E. This random walk in random environments has long(More)
My group studies binary systems composed of black holes and/or neutron stars. Einstein's theory of gravity, General Relativity (GR), was formulated in 1916 and passed many stringent experimental tests [1]. According to the theory, binary systems lose orbital energy to gravitational waves and get closer to each other (" in-spiral ") until they finally(More)
PURPOSE To evaluate the expression level of integrin αvβ3 on activated hepatic stellate cells (HSCs) at different stages of liver fibrosis induced by carbon tetrachloride (CCl4) in rat model and the feasibility to stage liver fibrosis by using molecular magnetic resonance imaging (MRI) with arginine-glycine-aspartic acid (RGD) peptide modified ultrasmall(More)
PURPOSE Arginine-glycine-aspartic acid (RGD)-based nanoprobes allow specific imaging of integrin αvβ3, a protein overexpressed during angiogenesis. Therefore, this study applied a novel RGD-coupled, polyacrylic acid (PAA)-coated ultrasmall superparamagnetic iron oxide (USPIO) (referred to as RGD-PAA-USPIO) in order to detect tumor angiogenesis and assess(More)
Personalized therapy provides the best outcome of cancer care and its implementation in the clinic has been greatly facilitated by recent convergence of enormous progress in basic cancer research, rapid advancement of new tumor profiling technologies, and an expanding compendium of targeted cancer therapeutics. We developed a personalized cancer therapy(More)