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Antioxidant flavonoid glycosides from aerial parts of the fern Abacopteris penangiana.
Five new flavan-4-ol glycosides, abacopterins E-I ( 5- 9), and seven known flavonoid glycosides ( 3 and 10- 15) were isolated from the aerial parts of the fern Abacopteris penangiana. TheirExpand
Systematic study on QAMS method for simultaneous determination of triterpenoid saponins in Ilex pubescens by HPLC and UPLC
The quantitative analysis of multi-components with single marker (QAMS) method was firstly established for simultaneous determination of six triterpenoid saponins (ilexgenin A (C1), ilexsaponin A1Expand
Comparative pharmacokinetics and tissue distribution of cryptotanshinone, tanshinone IIA, dihydrotanshinone I, and tanshinone I after oral administration of pure tanshinones and liposoluble extract
The results suggested that the coexisting constituents in the liposoluble extract of Salvia miltiorrhiza play an important role in the alteration of plasma concentration and tissue distribution of the four tanshinones. Expand
Protective effect of Wuzhi tablet (Schisandra sphenanthera extract) against cisplatin-induced nephrotoxicity via Nrf2-mediated defense response.
WZ tablet (WZ, a preparation of an ethanol extract of Schisandra sphenanthera) mitigates cisplatin-induced toxicity in renal epithelial HK-2 cells and in mice, and demonstrated WZ have a protective effect against cisplarin-induced nephrotoxicity by activation of the Nrf2 mediated defense response. Expand
Tanshinone IIA protects against acetaminophen-induced hepatotoxicity via activating the Nrf2 pathway.
It is demonstrated that Tan pretreatment could protect the liver from APAP-induced hepatic injury by activating the Nrf2 pathway and may provide a new strategy for the protection against AP AP-induced liver injury. Expand
Activation of the farnesoid X receptor attenuates triptolide-induced liver toxicity.
Results indicate that activation of FXR attenuates triptolide-induced hepatotoxicity and provide direct implications for the development of novel therapeutic strategies against triptoide- induced hepatot toxicity. Expand
Role of Nrf2 activation and NF-κB inhibition in valproic acid induced hepatotoxicity and in diammonium glycyrrhizinate induced protection in mice.
Diammonium glycyrrhizinate attenuates VPA-induced liver injury through increasing the expression of Nrf2 mediated phase II/antioxidant enzymes and simultaneously decreasing theexpression of inflammatory mediators. Expand
Flavan-4-ol Glycosides from the Rhizomes of Abacopteris penangiana.
Four new flavan-4-ol glycosides, abacopterins A-D (1-4), were isolated from a methanol extract of the rhizomes of Abacopteris penangiana and the cytotoxic activity of 1-5 against HepG2 human hepatoma cells was investigated. Expand
Valproate induced hepatic steatosis by enhanced fatty acid uptake and triglyceride synthesis
VPA‐triggered over‐regulation of CD36 and DGAT2 could be helpful for a better understanding of the mechanisms underlying VPA‐induced hepatic steatosis and may offer novel therapeutic strategies to combat V PA‐induced hepatotoxicity. Expand
3′,4′,5′,5,7-Pentamethoxyflavone Sensitizes Cisplatin-Resistant A549 Cells to Cisplatin by Inhibition of Nrf2 Pathway
It is demonstrated that PMF could be used as an effective adjuvant sensitizer to increase the efficacy of chemotherapeutic drugs by downregulating Nrf2 signaling pathway. Expand