Zhongtang Li

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OBJECTIVE To construct a zinc finger protein-artificial transcription factor (ZFP-ATF) specifically bound to hepatitis B virus (HBV) enhancer 1 (Enh1), then detect its expression in HepG2.2.15 cells, observe its effect on cell growth and its role in inhibiting the replication and expression of HBV DNA. METHODS The zinc finger protein (ZFP) specifically(More)
Consequences of primary dsysmenorrhea (PD) can be severe. Increased prostaglandin production leads to uterine contraction and insufficient blood flow to the endometrium causing ischemia and pain symptoms. Protein tyrosine kinase/phosphatase activities contribute to the modulation of uterine contraction. In our previous study, we found the synthetic(More)
IL-37 has been characterized as a fundamental inhibitor of innate immunity and a tumor suppressor in several cancers. However, the molecular mechanism of IL-37 in hepatocellular carcinoma (HCC) is largely unclear. In this study we found IL-37 expression was down-regulated in human HCC tissues and cell lines, and was negatively correlated with tumor size,(More)
OBJECTIVE To explore the impact of transcription factor 21 (TCF21) gene on proliferation, migration and apoptosis in SMMC-7721 hepatocellular carcinoma cell line and the related mechanism. METHODS Using Lipofectamine™2000, we stably transfected pcDNA3.1⁺TCF21 and pcDNA3.1⁺ plasmids into SMMC-7721 cells of TCF21 over-expression group and empty vector(More)
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