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Recurrent chimeric fusion RNAs in non-cancer tissues and cells
Gene fusions and their products (RNA and protein) were once thought to be unique features to cancer. However, chimeric RNAs can also be found in normal cells. Here, we performed, curated and analyzedExpand
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Foxm1 transcription factor is required for maintenance of pluripotency of P19 embryonal carcinoma cells
Transcription factor Foxm1 plays a critical role during embryonic development and its expression is repressed during retinoic acid (RA)-induced differentiation of pluripotent P19 embryonal carcinomaExpand
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Intergenically Spliced Chimeric RNAs in Cancer.
Gene fusions and their encoded products (fusion RNAs and proteins) are viewed as one of the hallmarks of cancer. Traditionally, they were thought to be generated solely by chromosomal rearrangements.Expand
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A chimeric RNA characteristic of rhabdomyosarcoma in normal myogenesis process.
UNLABELLED Gene fusions and their chimeric products are common features of neoplasia. Given that many cancers arise by the dysregulated recapitulation of processes in normal development, weExpand
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Functional heritage: the evolution of chimeric RNA into a gene
ABSTRACT Once believed to be unique features of neoplasia, chimeric RNAs are now being discovered in normal physiology. We speculated that some chimeric RNAs may be functional precursors of genes,Expand
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Increased levels of FoxA1 transcription factor in pluripotent P19 embryonal carcinoma cells stimulate neural differentiation.
Transcription factor FoxA1 plays a critical role during embryonic development and is activated during retinoic acid (RA)-induced neural differentiation of pluripotent P19 embryonal carcinoma cells atExpand
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Fusion transcriptome profiling provides insights into alveolar rhabdomyosarcoma
Significance Here, we propose an approach to study connections between biological samples. By using binary input of fusion RNA expression, samples of same or similar tissue origin were clusteredExpand
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Superlocalization spectral imaging microscopy of a multicolor quantum dot complex.
The key factor of realizing super-resolution optical microscopy at the single-molecule level is to separately position two adjacent molecules. An opportunity to independently localize targetExpand
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Foxm 1 transcription factor is required for maintenance of pluripotency of P 19 embryonal carcinoma cells
Transcription factor Foxm1 plays a critical role during embryonic development and its expression is repressed during retinoic acid (RA)-induced differentiation of pluripotent P19 embryonal carcinomaExpand
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PAX3-FOXO1 escapes miR-495 regulation during muscle differentiation
ABSTRACT Pax3 plays an essential role in myogenesis. Previously, we found a tumor-signature chimeric fusion RNA, PAX3-FOXO1 also present during muscle differentiation, raising the possibility of itsExpand
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