Zhongnan Zhang

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Many fundamental questions on aging are still unanswered or are under intense debate. These questions are frequently not addressable by examining a single gene or a single pathway, but can best be addressed at the systems level. Here we examined the modular structure of the protein-protein interaction (PPI) networks during fruitfly and human brain aging. In(More)
A hyperclique pattern [12] is a new type of association pattern that contains items which are highly affiliated with each other. More specifically, the presence of an item in one transaction strongly implies the presence of every other item that belongs to the same hyperclique pattern. In this paper, we present a new algorithm for mining maximal(More)
BACKGROUND AND THE PURPOSE OF THE STUDY As a novel drug in the treatment of cardiac diseases, dl-praeruptorin A (Pd-Ia) is the major active component of traditional herbal medicine Peucedanum praeruptorum Dunn and is metabolized primarily via cytochrome P450 isozymes (CYP) 3A1 and 3A2 in rats. In the present study, the influence of liver cirrhosis on(More)
Unmanned aerial vehicle (UAV) has been widely used in many industries. In the medical environment, especially in some emergency situations, UAVs play an important role such as the supply of medicines and blood with speed and efficiency. In this paper, we study the problem of multi-objective blood supply by UAVs in such emergency situations. This is a(More)
An in-wheel motor electric vehicle has high unsprung mass because of its in-wheel motor, which decreases vehicle ride comfort and vehicle safety. This paper presents a controllable suspension employing an optimal design hybrid damping control strategy based on ideal skyhook and groundhook as a reference. A sliding mode controller is designed to make the(More)