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BACKGROUND Small non-coding RNAs (sRNAs) facilitate host-microbe interactions. They have a central function in the post-transcriptional regulation during pathogenic lifestyles. Hfq, an RNA-binding protein that many sRNAs act in conjunction with, is required for Y. pestis pathogenesis. However, information on how Yersinia pestis modulates the expression of(More)
Cardiovascular disease is the leading cause of human morbidity and mortality. Dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy associated with heart failure. Here, we report that cardiac-specific knockout of Dicer, a gene encoding a RNase III endonuclease essential for microRNA (miRNA) processing, leads to rapidly progressive DCM,(More)
Skeletal muscle satellite cells are adult stem cells responsible for postnatal skeletal muscle growth and regeneration. Paired-box transcription factor Pax7 plays a central role in satellite cell survival, self-renewal, and proliferation. However, how Pax7 is regulated during the transition from proliferating satellite cells to differentiating myogenic(More)
OBJECTIVE To construct adenovirus expressing NGF (Ad-NGF) and to investigate its promotive effect on the reparation and regeneration of sciatic nerve injury in rats. METHODS NGF gene sequence was cloned into shuttle plasmid pCA13 of adenovirus type 5. After packed in HEK-293 cells, the recombinant adenoviruses-Ad-NGF underwent sequence identification.(More)
BACKGROUND MicroRNAs (miRNAs) are a class of non-coding regulatory RNAs of ~22 nucleotides in length. miRNAs regulate gene expression post-transcriptionally, primarily by associating with the 3' untranslated region (UTR) of their regulatory target mRNAs. Recent work has begun to reveal roles for miRNAs in a wide range of biological processes, including cell(More)
This study was designed to investigate the molecular mechanisms responsible for the induction of proinflammatory cytokines gene expression and apoptosis in human monocytic cell line THP-1 stimulated by lipoproteins (LPs) prepared from Mycoplasma genitalium. Cultured cells were stimulated with M. genitalium LP to analyze the production of proinflammatory(More)
An integrated location algorithm using satellite location and wireless sensor networks (WSN) is put forward to solve the issues of seamless location both indoors and outdoors in a pervasive computing environment in this paper. Pseudorange observation data of global positioning system (GPS) and distance observation data of WSN are utilized to carry out(More)
The location technology based on time difference of arrival (TDOA) is one of the key technologies in The 3rd Generation Telecommunication. In this paper, TDOA positioning method based on modified Chan algorithm for CDMA2000 mobile network is proposed. Pilot delay measurement is adopted to realize TDOA positioning parameter detection. A mathematical model of(More)
For the goal of seamless indoor and outdoor location based services(LBS), a integrated navigation algorithm with both satellite location and WSN is put forward in this paper. This paper also design semi- physical simulation platform based on software receiver structure, which integrate GPS receiver and WSN nodes. Pseudorange observation data of global(More)
—The Location based services (LBS) are become increasingly important on telecommunication applications. Many LBS methods have been developed. of Arrival (OTDOA), and other third Generation (3G) location technologies, are evaluated in the paper. Above of all, the Assisted GNSS (A-GNSS) is analyzed to settle for emergency LBS. The technical advantages to(More)