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Amorphous silica nanoparticles are widely applied in many fields. But the adverse effects of silica nanoparticle exposure were unclear. The present study investigated the cytotoxicity and mitochondrial damage of silica nanoparticles exposure in hepatocellular carcinoma cell line (HepG2). The cells were treated with 43 nm non-modified amorphous silica(More)
The purpose of this work was to investigate the cardiovascular toxicity of different sizes and different dosages of silica nanoparticles in Wistar rats. The three silica nanoparticles (30, 60, and 90 nm) and one fine silica particles (600 nm) at three doses of 2, 5, and 10 (mg/Kg bw) were used in the present experiment. After intratracheal instillation for(More)
The purpose of this study is to compare the potential cytotoxicity induced by amorphous silica particles with different sizes. The effects of one fine particle (498 nm) and three nanoparticles (68, 43, and 19 nm) on cultured human hepatoma (HepG2) cells were investigated by detecting morphological changes, cell viability, cytomembrane integrity, DNA damage,(More)
This study aimed to evaluate the acute toxicity of intravenously administrated amorphous silica nanoparticles (SNPs) in mice. The lethal dose, 50 (LD50), of intravenously administrated SNPs was calculated in mice using Dixon's up-and-down method (262.45±33.78 mg/kg). The acute toxicity was evaluated at 14 d after intravenous injection of SNPs at 29.5, 103.5(More)
Glycogen synthase kinase-3 (GSK-3) is a key protein kinase involved in numerous cellular processes, including embryonic development, protein synthesis, glycogen metabolism, mitosis and apoptosis. However, our knowledge of Schizothorax prenanti GSK-3 is very limited. In this study, we cloned and characterized the S. prenanti GSK3β gene. Using qPCR, we found(More)
The mechanisms behind the repairing effects of the cotransplantation of olfactory ensheathing cells (OECs) with bone marrow mesenchymal stromal cells (BMSCs) have not been fully understood. Therefore, we investigated the effects of the cotransplantation of OECs with BMSCs on antiapoptotic effects in adult rats for which the models of SCI are induced. We(More)
In many circumstances, the structural conflicts in workflow processes lead to malfunctioning of workflow management systems. So the conflicts should be detected and resolved before workflow processes are actually put into execution. Up to now, there is still no effective algorithm which can be able to detect out the structural conflicts both in the workflow(More)
People have benefited a lot from the fast development of the Internet, but at the same time, it also spreads harmful and erotic content widely. Compared with the past when the researchers concentrated on the mechanical filtering and text-based filtering, they have more focused on the researches of image-based filtering and fusion algorithm filtering now.(More)
The nearest neighbor wouldn't be replaced by any other dataset while query point didn't cross over the border of the safe area. However, it is hard to work out the traditional safe area which is an irregular spatial region. In this paper, we designed spherical safe area to resolve the above-mentioned problem, and proved the procedure of calculation is(More)
  • Cunxiang Bo, Wei Zhao, +7 authors Zhenling Zhang
  • International journal of clinical and…
  • 2015
AIMS To investigate the mechanisms of α-zearalanol (Zeranol)-induced male reproductive toxicity, the effects of Zeranol on spermatogenesis and sex hormone levels of male mice were studied. METHODS Forty healthy sexually mature male Kunming mice were randomly divided into four groups. The mice were mock-treated or treated with Zeranol 25, 50 or 100 mg/kg(More)