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Acquisition of anoikis-resistance is a pre-requisite for cancer cell metastasis. We have demonstrated that hepatoma cells could resist anoikis by a synoikis-like survival style. In this study, we further suggest that acquisition of anoikis-resistance confer cancer cells more capacity for invasiveness, evading from cancer therapeutic agents and escaping from(More)
Tumor necrosis factor-alpha-induced protein-8 like-2 (TNFAIP8L2, TIPE2) is a newly discovered negative regulator of innate immunity and cellular immunity. TIPE2 deficiency in mice causes fetal inflammatory diseases and TIPE2 downregulation in humans is associated with systemic autoimmunity. However, TIPE2 deficiency leads to a selective defect in humoral(More)
Resistance to anoikis is a hallmark of human malignancies. Our results showed that hepatoma cells resisted anoikis by non-proliferation, non-apoptosis and cell cycle arrest which were termed synoikis-like. These synoikis-like cells are more resistant to extracellular stimuli and could spontaneously attach and proliferate again under suitable conditions,(More)
Sustained Toll-like receptor (TLR) stimulation continuously activates antimicrobial genes but paradoxically represses inflammatory genes. This phenomenon, termed TLR tolerance, is essential for preventing fatal inflammatory conditions such as sepsis, but its underlying mechanisms are unclear. We report here that NF-κB binding nucleic acids of gene promoters(More)
Hepatitis B virus (HBV)-induced hepatic inflammation afflicts hundreds of millions of people worldwide and is a leading cause of hepatic cancer. While the deleterious effect of the chronic hepatitis is well recognized, the molecular mechanisms underlying the pathogenesis of HBV-induced hepatic inflammation are not well understood. We report here that the(More)
Online forum is an important source that people use to find answers to questions. Most search engines simply retrieve " relevant " threads, but those are not necessarily good threads in terms of providing quality answers. In this paper we propose a two-step approach to classify online forum threads according to their informativeness in terms of question(More)
The number of users on Twitter has drastically increased in the past years. However, Twitter does not have an effective user grouping mechanism. Therefore tweets from other users can quickly overrun and become inconvenient to read. In this paper, we propose methods to help users group the people they follow using their provided seeding users. Two sources of(More)
A Connected Dominating Set (CDS) can be used to construct a virtual backbone for wireless and mobile ad-hoc networks to make the system hierarchical and efficient. A virtual backbone can significantly improve network throughput, optimize broadband utilization, extend network lifetime, and reduce interference as well as packet retrans-missions. Calculating a(More)