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Late-stage tumors induce anemia and immunosuppressive extramedullary erythroid progenitor cells
TLDR
Large tumors induce anemia and expansion of CD45+ immature erythroid cells, which represent a major immunosuppressive population in the spleen, contributing to systemic suppression of T cell immunity in late-stage cancer. Expand
Ovarian cancer stem-like cells differentiate into endothelial cells and participate in tumor angiogenesis through autocrine CCL5 signaling.
TLDR
This study found that ovarian cancer stem-like cells (CSLCs) activate the NF-κB and STAT3 signal pathways through autocrine CCL5 signaling and mediate their own differentiation into endothelial cells (ECs), and provides a novel strategy for anti-angiogenesis in ovarian cancer. Expand
EZH2 Inhibitor GSK126 Suppresses Antitumor Immunity by Driving Production of Myeloid-Derived Suppressor Cells.
TLDR
It is reported that suppressing EZH2 activity using GSK126 resulted in increased numbers of myeloid-derived suppressor cells (MDSC) and fewer CD4+ and IFNγ+CD8+ T cells, which are involved in antitumor immunity, and suggested that modulating the tumor immune microenvironment may improve the efficacy of EZh2 inhibitors. Expand
Aberrant elevated microRNA-146a in dendritic cells (DC) induced by human pancreatic cancer cell line BxPC-3-conditioned medium inhibits DC maturation and activation
TLDR
It is indicated that aberrant miRNA-146a expression is one of main factors responsible for inhibition of DC maturation and antigen presentation function, and this inhibitory effect on DCs may be due to the repression of Smad4 mediated signal pathway by BxCM. Expand
Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation
TLDR
It is shown that EZH2 inhibitors attenuate experimental colitis in mice by promoting the development of myeloid-derived suppressor cells, and delay the onset of colitis-associated cancer. Expand
microRNA-214 promotes epithelial-mesenchymal transition and metastasis in lung adenocarcinoma by targeting the suppressor-of-fused protein (Sufu)
TLDR
This study finds that the expression of miR-214 was elevated in LAD and correlated positively with LAD metastasis and epithelial-mesenchymal transition (EMT), and uncovers a previously unappreciated mi R-214-Sufu pathway in controlling EMT and metastasis of LAD. Expand
Integrin-β5, a miR-185-targeted gene, promotes hepatocellular carcinoma tumorigenesis by regulating β-catenin stability
TLDR
The data reveal that the miR-185-ITGB5-β-catenin pathway plays an important role in HCC tumorigenesis, and ITGB5 may be a promising specific target for HCC therapy. Expand
Immunotherapeutic effects on murine pancreatic carcinoma by β-elemene combined with dendritic cells modified with genes encoding interleukin-23
TLDR
Results showed inhibitory effects on tumor cells and increased survival time in the experimental group treated with the vaccine combined with β-elemene, and IL-23-modified dendritic cell vaccines enhance specific Th1-type and cytotoxic T lymphocyte responses against pancreatic carcinoma cells. Expand
Induction of CTLs by DCs pulsed with K-ras mutant peptide on the surface of nanoparticles in the treatment of pancreatic cancer.
TLDR
Investigating the role of specific cytotoxic T lymphocytes activated by dendritic cells (DCs) presenting cationic nanoparticles with the K-ras (12-Val) mutant peptide in the killing of different pancreatic cancer cell lines confirmed that whole cell antigen induced a good antitumor immune response. Expand
EZH2 regulates PD-L1 expression via HIF-1α in non-small cell lung cancer cells.
TLDR
EZH2 regulates the immunosuppressive molecule PD-L1 expression via HIF-1α in non-small cell lung cancer cells, thus delaying lung cancer progression in vivo by enhancing anti-tumor immune responses. Expand
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