Zhong-tang Feng

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This study investigated the effects of bone marrow stromal cells transplantation on Alzheimer's disease (AD). Bone marrow stromal cells (BMSC) were obtained from the bone marrow of transgenic mice expressing green fluorescent protein and transplanted into the hippocampus of rats, which had received an injection of beta amyloid protein into the hippocampus 8(More)
This investigation studied the temporal changes in the expression of GDNF and FGF-2 in the left sixth lumbar (L6) dorsal root ganglion (DRG) after acupuncture in adult cats subjected to unilateral removal of adjacent DRG. The cats were divided into three groups. Group I were normal control animals. Group II cats were subjected to removal of DRG associated(More)
Immunohistochemical distribution and cellular localization of neurotrophins was investigated in adult monkey brains using antisera against nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). Western blot analysis showed that each antibody specifically recognized appropriate bands of(More)
This study determined the effects of pcDNA3-β-nerve growth factor (NGF) gene-modified bone marrow stromal cells (BMSC) on the rat model of Parkinson’s disease (PD). The recombinant plasmid pcDNA3-β-NGF was transfected into BMSC, and NGF expression and its biological activity in vitro were detected. BMSC modified by the NGF gene were then grafted into the(More)
It is well known that bone marrow stromal cells (BMSC) grafted into the hippocampus of the rat model of Alzheimer’s disease (AD) could survive and differentiate into cholinergic neurons as well as contribute towards functional restoration. The present study evaluated the effects of BMSC as a seed cell modified by nerve growth factor (NGF) gene into the(More)
OBJECTIVE To investigate the distribution and change of NGF, BDNF and NT3 in hippocampus of rat with Alzheimer disease(AD) by immunohistochemistry. METHODS AD model was established by injecting beta amyloid protein into the hippocampus of rat. The rats were killed ten days after injection. The hippocampus sections were made coronally on a freezing(More)
This study examined the protein expression profile changes in the brain of senescence-accelerated mice/prone 8 (SAMP8) model. Two approaches, namely microarray and RT-PCR, were used in the study. Four genes, which are orthologous to human, were found to differentially express in the aging brain of mice. In this study, we examined the differentially(More)
OBJECTIVE To explore the effect of kallikrein-binding protein (KPB) in protecting retinal ganglion cells (RGCs) and promoting axonal regeneration following optical nerve injury in rats. METHODS Crush injury of the optic nerve at 0.5-1.0 mm from the eyeball was induced in rats, which received subsequent KBP injection into the vitreous cavity (experimental(More)
OBJECTIVE To establish spinal cord half-transection model in rhesus and investigate the Four neurological function and morphologic changes following spinal cord hemisection in rhesus. METHODS Four cynomolgus monkeys were subjected to T-11 laminectomy and resection of a 1-mm length of hemispinal cord, while the controls underwent the identical laminectomy(More)
The role of sodium channel voltage-gated beta 2 (SCN2B) in brain aging is largely unknown. The present study was therefore designed to determine the role of SCN2B in brain aging by using the senescence-accelerated mice prone 8 (SAMP8), a brain senescence-accelerated animal model, together with the SCN2B transgenic mice. The results showed that SAMP8(More)