Zhong-jian Chen

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SCOPE The study aimed to investigate the regioselectivity of methylation of luteolin (3',4',5,7-tetrahydroxyflavone) in human in vitro and in vivo. METHODS AND RESULTS Recombinant human catechol-O-methyltransferase (COMT) and human liver S9 were utilized to study the kinetics of meta (3')- and para (4')- methylation of luteolin, and urine samples from(More)
The flower of Chrysanthemum morifolium Ramat (CM) is an established part of traditional Chinese medicine (TCM). Luteolin and apigenin flavonoids are the effective components of the CM extract (CME); however, they exist in the orally consumed CME as glycosides. The present study was carried out to determine the relative contribution of the small and large(More)
Dear Editor: Colorectal cancer is one of the most common malignant tumors with poor prognosis. New strategies, combined chemotherapies, and antiangiogenesis agents improved the overall survival, but the side effect was also more complicated. Here, we presented a colon cancer patient who underwent subcutaneous tuberculosis during combined therapy of FOLFIRI(More)
Catechol-O-methyltransferase (COMT, EC 2.1.1.6) plays a central role in the inactivation of neurotransmitters sharing a catecholic motif by transferring a methyl group from AdoMet. Methylation of the meta-hydroxyl is much more common than that of the para-hydroxyl in many COMT substrates, such as dopamine and norepinephrine. Our experimental data showed(More)
Objective: Summarise the analysis of experience and effect of surgical treatment of total anomalous pulmonary venous connection (TAPVC) on neonates. Method: there were 54 patients of neonates TAPVC selected from March, 2011 to March, 2015, among the surgical treatments in our department, including 33 males and 21 females. Operation age is 6 days -28 days(More)
As a widely used and expensive herbal medicine, Panax ginseng has many adulterants in the commercial market. PCR-restriction fragment length polymorphism (PCR-RFLP) and amplification refractory mutation system (ARMS) based on 5S rDNA sequence analysis were applied to identify two common adulterants of P. ginseng. The sizes of 5S rRNA gene non-transcribed(More)
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