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OBJECTIVES/HYPOTHESIS To investigate changes in parotid and submandibular gland volumes of patients with head and neck cancer treated with postoperative intensity-modulated radiotherapy (IMRT) or conventional radiotherapy (CRT), and to relate the volume changes to different mean radiation therapy (RT) doses to the parotid and submandibular glands. METHODS(More)
PURPOSE To evaluate induction chemotherapy with docetaxel, cisplatin, and fluorouracil (TPF) followed by surgery and postoperative radiotherapy versus up-front surgery and postoperative radiotherapy in patients with locally advanced resectable oral squamous cell carcinoma (OSCC). PATIENTS AND METHODS A prospective open-label phase III trial was conducted.(More)
PURPOSE To observe the recovery of saliva output and effect on xerostomia grade after intensity-modulated radiotherapy (IMRT) with or without contralateral submandibular gland (cSMG) sparing and to assess the impact of salivary gland dosimetry on this recovery among patients with head-and-neck cancer. METHODS AND MATERIALS Between May 2007 and May 2008,(More)
OBJECTIVES/HYPOTHESIS Is the severity of acute oral mucositis in patients who receive postoperative intensity-modulated radiotherapy (PO-IMRT) for oral tongue squamous cell carcinoma (SCC) reduced by sparing the oral mucosa outside of the planning target volume (PTV)? STUDY DESIGN Prospective, randomized trial. METHODS Forty-eight patients with oral(More)
This is an analysis of 103 patients with squamous cell carcinoma of the head and neck treated with preoperative radiation therapy (4000-6143 cGy; mean 4980 cGy) followed by primary resection and neck dissection. Patients were treated between March 1965 and April 1985; there was a minimum 2-year follow-up. Most of the patients in this study had clinical(More)
This study was undertaken to evaluate the influence of radiotherapy (RT) on reconstructive flaps after radical excision of head and neck cancer. Eighty-eight reconstructive flaps were used in 82 patients who received RT either before (PREOP group, 14 flaps) or after (POSTOP group, 74 flaps) surgery. The success and healing rates of the flaps were evaluated.(More)
Previously, we conducted a randomized phase III trial of TPF (docetaxel, cisplatin, and 5-fluorouracil) induction chemotherapy in surgically managed locally advanced oral squamous cell carcinoma (OSCC) and found no improvement in overall survival. This study reports long-term follow-up results from our initial trial. All patients had clinical stage III or(More)
BACKGROUND We compared outcomes and xerostomia grade after postoperative intensity-modulated radiation therapy (IMRT) and conventional radiotherapy (RT) in patients with oral and oropharyngeal carcinoma. METHODS Eighty-eight patients with oral cavity (n = 77) and oropharyngeal (n = 11) carcinoma underwent postoperative IMRT (n = 44) or conventional RT (n(More)
OBJECTIVE To study the impact of postoperative radiotherapy (RT) on titanium plate mandibular reconstruction. METHODS Between 1997 and 2002, 66 patients with oral cavity cancers had immediate titanium plate mandibular reconstruction. Thirty-four patients (51.5%) received postoperative RT and 32 patients were treated with surgery alone. Follow-up ranged(More)
This current work is concerned with the modification of sugar beet pulp (SBP) pectin assisted by pulsed electric filed (PEF) without solvent. Pectin-arachates with degree of esterification (DE) ranging from 49 to 84 were prepared in one-step modification. The results showed that the DE of pectin derivatives increased significantly with the PEF intensity(More)