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Geissoschizine methyl ether, a corynanthean-type indole alkaloid from Uncaria rhynchophylla as a potential acetylcholinesterase inhibitor
TLDR
A newly discovered strong acetylcholinesterase (AChE) inhibitor, along with six weakly active alkaloids, vallesiachotamine (2), hisuteine (3), hirsutine (4), isorhynchophylline (5), cisocorynoxeine (6) and corynoxEine (7) have been isolated from Uncaria rhyn chophylla.
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Steroidal alkaloids from Holarrhena antidysenterica as acetylcholinesterase inhibitors and the investigation for structure-activity relationships.
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Modified TLC bioautographic method for screening acetylcholinesterase inhibitors from plant extracts.
TLDR
Modifications to an existing TLC bioautographic method for detecting acetylcholinesterase inhibitors from plant extracts were described, and the consumption of the enzyme was reduced by 85% and the detection limits were decreased remarkably.
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An aporphine alkaloid from Nelumbo nucifera as an acetylcholinesterase inhibitor and the primary investigation for structure–activity correlations
TLDR
N-methylasimilobine, a new-found strong acetylcholinesterase (AChE) inhibitor, along with two weakly active aporphine alkaloids, nuciferine and nornuciferines, were separated from Nelumbo nukifera and molecular modelling was performed to explore the binding mode of inhibitor 1 at the active site of AChE.
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A Peroxidase-linked Spectrophotometric Assay for the Detection of Monoamine Oxidase Inhibitors
TLDR
The ⊿OD value between the blank group and blank negative control group in this new method is twice as much as that in Holt’s method, which enables the procedure to be more accurate and avoids the produce of false positive results.
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Acetylcholinesterase inhibitory activity of the total alkaloid from traditional Chinese herbal medicine for treating Alzheimer’s disease
TLDR
The results of this study indicate that the screening of traditional Chinese herbs for AChE inhibitory activity may provide useful lead compounds in the discovery of new drugs for the treatment of AD.
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Sesquiterpenoids from the root tubers of Lindera aggregata.
Six new sesquiterpenoids, linderanlide A-F (1-5 and 12), and nine previously reported sesquiterpenoids (6-11 and 13-15) have been isolated from the root tubers of Lindera aggregata. The new…
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Eudesmane derivatives and other constituents from Saussurea parviflora.
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Desmodeleganine, a new alkaloid from the leaves of Desmodium elegans as a potential monoamine oxidase inhibitor.
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Skimmianine, a furoquinoline alkaloid from Zanthoxylum nitidum as a potential acetylcholinesterase inhibitor
TLDR
The structure activity relationship on the anti-acetylcholinesterase activity of the quinoline moiety is discussed in this article and supported by TLC bioautographic assay.
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