Zhong-chao Han

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Hypoxia-inducible factor (HIF)-1 alpha directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF).

Zhi-bo Han, He Ren, +8 authors Zhong-chao Han
Carcinogenesis
2008

Stem cell factor (SCF) plays important roles in tumor growth and angiogenesis. However, its regulatory mechanism remains largely undefined. Here, we report that hypoxia upregulated the expression of… (More)

Molecular mechanisms involved in self-renewal and pluripotency of embryonic stem cells.

Na Liu, Min Lu, Xuemei Tian, Zhong-chao Han
Journal of cellular physiology
2007

Embryonic stem cells (ES cells) are derived from inner cell mass (ICM). The self-renewal and pluripotency are the main specificities of ES cells, which are likely to reveal a deeper understanding of… (More)

Retroviruses pseudotyped with the severe acute respiratory syndrome coronavirus spike protein efficiently infect cells expressing angiotensin-converting enzyme 2.

Michael J. Moore, Tatyana Dorfman, +9 authors Hyeryun Choe
Journal of virology
2004

Infection of receptor-bearing cells by coronaviruses is mediated by their spike (S) proteins. The coronavirus (SARS-CoV) that causes severe acute respiratory syndrome (SARS) infects cells expressing… (More)

Transplantation of human embryonic stem cell-derived endothelial cells for vascular diseases.

Zongjin Li, Zhong-chao Han, Joseph C Wu
Journal of cellular biochemistry
2009

Using endothelial cells for therapeutic angiogenesis/vasculogenesis of ischemia diseases has led to exploring human embryonic stem cells (hESCs) as a potentially unlimited source for endothelial… (More)

Extracellular Matrix can Recover the Downregulation of Adhesion Molecules after Cell Detachment and Enhance Endothelial Cell Engraftment

Ningning He, Yang Xu, +11 authors Zongjin Li
Scientific reports
2015

The low cell engraftment after transplantation limits the successful application of stem cell therapy and the exact pathway leading to acute donor cell death following transplantation is still… (More)

Anti-angiogenesis effects of meisoindigo on chronic myelogenous leukemia in vitro.

Zhijian Xiao, Yi Wang, +4 authors Yushu Hao
Leukemia research
2006

Meisoindigo, an active compound of a Chinese anti-leukemia medicine, has been effectively used in the treatment of chronic myelogenous leukemia (CML). Increasing evidences have demonstrated that… (More)

Functional characterization and expression profiling of human induced pluripotent stem cell- and embryonic stem cell-derived endothelial cells.

Zongjin Li, Shijun Hu, Zhumur Ghosh, Zhong-chao Han, Joseph C Wu
Stem cells and development
2011

With regard to human induced pluripotent stem cells (hiPSCs), in which adult cells are reprogrammed into embryonic-like cells using defined factors, their functional and transcriptional expression… (More)

Human umbilical cord blood cells express neurotrophic factors

Cun-Gang Fan, Qing-jun Zhang, Feng-wu Tang, Zhi-bo Han, Ge-Sheng Wang, Zhong-chao Han
Neuroscience Letters
2005

Freshly isolated or culture-expanded human umbilical cord blood mononuclear cells (CBMNCs) have been known to express neural phenotypes in vitro and to differentiate into neural cells and improve… (More)

Neural ganglioside GD2 identifies a subpopulation of mesenchymal stem cells in umbilical cord.

Jie Xu, Wenbin Liao, +9 authors Zhong-chao Han
Cellular physiology and biochemistry…
2009

In contrast to hematopoietic stem cells, there is still a lack of definitive cell markers for specific isolation and identification of mesenchymal stem cells (MSCs). Thus a homogenous population of… (More)

Suppression of ABCG2 inhibits cancer cell proliferation.

Zhong Chen, Fang Liu, +5 authors Zhong-chao Han
International journal of cancer
2010

The ATP-binding cassette efflux transporter, ABCG2, is widely expressed in a variety of normal tissues, stem cells, as well as cancer cells. Existing data suggest that ABCG2 plays an important role… (More)

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