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Polybromo protein BAF180 functions in mammalian cardiac chamber maturation.
TLDR
It is shown that the ablation of PBAF-specific subunit BAF180 in mouse embryos results in severe hypoplastic ventricle development and trophoblast placental defects, similar to those found in mice lacking RXRalpha and PPARgamma.
Adipose tissue-derived stem cells secrete CXCL5 cytokine with neurotrophic effects on cavernous nerve regeneration.
TLDR
CXCL5 was secreted by ADSC at a high level, promoted MPG neurite growth, and activated JAK/STAT in Schwann cells, which may contribute to ADSC's therapeutic efficacy on CN injury-induced ED.
BMSC-Derived Exosomal miR-29a Promotes Angiogenesis and Osteogenesis
TLDR
It is reported that bone marrow mesenchymal stem cell (BMSC)-derived exosomal miR-29a promotes angiogenesis and osteogenesis in vitro and in vivo, and miR29a-loaded BMSCs-Exos may serve as a potential therapeutic target for osteoporosis.
The H3K27 demethylase, Utx, regulates adipogenesis in a differentiation stage-dependent manner
TLDR
The data suggest that Utx governs adipogenesis by regulating c-Myc in a differentiation stage-specific manner and that targeting the Utx signaling pathway could be beneficial for the treatment of obesity, diabetes, and congenital utx-deficiency disorders.
PCAF acetylates Runx2 and promotes osteoblast differentiation
TLDR
Results indicate that PCAF is an important regulator for promoting osteoblast differentiation via acetylation modification of Runx2, and p300/CBP-associated factor knockdown decreases the mRNA levels of ALP, Ocn, and Opn.
Decreased MiR-17 in glioma cells increased cell viability and migration by increasing the expression of Cyclin D1, p-Akt and Akt
TLDR
The reduced miR-17 levels in glioma cells increased cell viability and migration, which correlates with increased expression of Cyclin D1, p-Akt and Akt.
Identification of differential expressed lncRNAs in human thyroid cancer by a genome‐wide analyses
TLDR
The findings reveal that lots of lncRNAs are dysregulated and may play critical roles in thyroid cancer, and this study could provide useful resource for identification and investigation of novel lncRNA candidates for thyroid cancer.
Differential Gene Expression in Tamoxifen-Resistant Breast Cancer Cells Revealed by a New Analytical Model of RNA-Seq Data
Resistance to tamoxifen (Tam), a widely used antagonist of the estrogen receptor (ER), is a common obstacle to successful breast cancer treatment. While adjuvant therapy with Tam has been shown to
IQGAP1 promotes pancreatic cancer progression and epithelial-mesenchymal transition (EMT) through Wnt/β-catenin signaling
TLDR
Overexpression of IQGAP1 increased the protein level of Dishevelled2 and enhanced canonical Wnt signaling as evidenced by increased DVL2 level and β-catenin transcriptional activity, β-Catenin nuclear translocation and expression of the direct target genes of β- catenin (cyclin D1 and c-myc).
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