Zhong Jian

Ye Chen-Izu3
Jian-Hong Duan2
Tamas Banyasz2
San-Jue Hu2
3Ye Chen-Izu
2Jian-Hong Duan
2Tamas Banyasz
2San-Jue Hu
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The cardiac action potential (AP) is shaped by myriad ionic currents. In this study, we develop an innovative AP-clamp Sequential Dissection technique to enable the recording of multiple ionic currents in the single cell under AP-clamp. This new technique presents a significant step beyond the traditional way of recording only one current in any one cell.(More)
Injured dorsal root ganglion (DRG) neurons often develop adrenergic sensitivity. To investigate the mechanisms of this phenomenon, the effects of norepinephrine (NE) on membrane potential of large- and medium-sized A-type neurons from chronically compressed DRG were recorded electrophysiologically in vitro. NE induced a depolarization in both control(More)
  • Zhong Jian, Yi-Je Chen, Rafael Shimkunas, Yuwen Jian, Mark Jaradeh, Karen Chavez +5 others
  • 2016
Isolation of high quality cardiomyocytes is critically important for achieving successful experiments in many cellular and molecular cardiology studies. Methods for isolating cardiomyocytes from the murine heart generally are time-sensitive and experience-dependent, and often fail to produce high quality cells. Major technical difficulties can be related to(More)
β-Adrenergic stimulation differentially modulates different K+ channels and thus fine-tunes cardiac action potential (AP) repolarization. However, it remains unclear how the proportion of I Ks, I Kr, and I K1 currents in the same cell would be altered by β-adrenergic stimulation, which would change the relative contribution of individual K+ current to the(More)
TRPC6 is a ubiquitous and predominant isoform expressed in vascular smooth muscle cells (VSMCs) and has been implicated in the regulation of vascular tone and remodelling via neurohormonal and mechanosensitive mechanisms. Although these two mechanisms are generally thought to work independently, our recent investigation has revealed that TRPC6 channel is(More)
Short-term plasticity (STP) is an important element of information processing in neuronal networks. As the first synaptic relay between primary afferent fibers (PAFs) and central neurons, primary afferent synapses in spinal dorsal horn (DH) are essential to the initial processing of somatosensory information. In this research, we examined the STP between(More)
Taking cats as experiment animal model, the chaotic characteristics of postganglionic inferior cardiac sympathetic nerve activity (PICSNA) is analyzed with Cao method, correlation dimension analysis and largest Lyapunov exponent analysis. The analysis results show that the deterministic chaos lies in the peak-peak interval time series of PICSNA. Our work(More)
To demonstrate the age-related changes in the dynamics of the nociceptive discharge of dorsal horn nociceptive neurons, the nonlinear prediction method was used to quantify the degree of deterministic behavior within the interspike interval series of tissue injury-induced firing of spinal nociceptive neurons in anesthetized adult young (3-4 months) and aged(More)
The aim of this study was to develop a new method of epileptic prediction using nonlinear dynamic theory. When rat was falling sickness, its EEG was researched by using approximate entropy and correlation dimension. The results showed the approximate entropy and correlation dimension during epileptic seizure are obviously lower than those before seizure and(More)