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Impaired GABAergic inhibitory synaptic transmission plays an essential role in the pathogenesis of selective neuronal cell death following transient global ischemia. GABA(A) receptor (GABA(A)R), K⁺-Cl⁻ co-transporter 2 (KCC2), Na⁺-K⁺-Cl⁻ co-transporter 1 (NKCC1) and astrocytes are of particular importance to GABAergic transmission. The present study was(More)
In biomedical signal processing, Gibbs oscillation and severe frequency aliasing may occur when using the traditional discrete wavelet transform (DWT). Herein, a new denoising algorithm based on the dual-tree complex wavelet transform (DTCWT) is presented. Electrocardiogram (ECG) signals and heart sound signals are denoised based on the DTCWT. The results(More)
Objective: This article describes a novel method for processing continuous intracranial pressure (ICP) signals with lifting wavelet transformation and discrimination rules for ICP waveform morphology. Methods: First, lifting wavelet was applied to detect the extreme points of ICP waveform preliminarily; then, the extreme points that were undetected or(More)
OBJECTIVE To investigate whether the intermittent hypothermia (IH) protects neurons against ischemic insult and the potential molecular targets using an in vitro ischemic model of oxygen glucose deprivation (OGD). METHODS Fetal rat cortical neurons isolated from Day E18 rat embryos were subjected to 90-min OGD and hypothermia treatments during(More)
The study explored a modified primary culture system for fetal rat cortical neurons. Day E18 embryos from pregnant Sprague Dawley rats were microdissected under a stereoscope. To minimize enzymatic damage to the cultured neurons, we applied a sequential digestion protocol using papain and Dnase I. The resulting sifted cell suspension was seeded at a density(More)
Topiramate (TPM) was previously found to have neuroprotection against neuronal injury in epileptic and ischemic models. However, whether TPM protects against glutamate-induced excitotoxicity in hippocampal neurons is elusive. Our present work aimed to evaluate the protective effect of TPM against glutamate toxicity in hippocampal neurons and further figure(More)
Dimensionality reduction is a key step to improving the generalization ability of reranking in image search. However, existing dimensionality reduction methods are typically designed for classification, clustering, and visualization, rather than for the task of learning to rank. Without using of ranking information such as relevance degree labels, direct(More)
In the clinical analysis and processing for EEG, because of the difference of ages and pathology, it is possible to appear abnormal waves related with pathology. Also, the restrain of normal rhythms could be abnormal. But at present doctors estimate if certain rhythm is restrained only by using the method of eyeballing or by some simply analysis methods in(More)