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Natural products inhibiting Candida albicans secreted aspartic proteases from Lycopodium cernuum.
Activity-guided fractionation of an ethanol extract of Lycopodium cernuum for Candida albicans secreted aspartic proteases (SAP) inhibition resulted in the identification of six new (1-6) and four
An Overview of Genus Aesculus L.: Ethnobotany, Phytochemistry, and Pharmacological Activities
TLDR
The objective of this paper is to review the ethnobotany, phytochemistry, and pharmacological properties of the genus Aesculus and to further confirm the chemotaxonomic value of the novel cytotoxic saponins discovered recently from A. pavia, an eastern North American species.
Fatty acid synthase inhibitors from plants: isolation, structure elucidation, and SAR studies.
TLDR
Three'-Formylgenistein and ellagic acid 4-O-alpha-l-rhamnopyranoside were the most potent compounds against FAS, with IC(50) values of 2.3 and 7.5 microg/mL, respectively.
New Capoamycin-Type Antibiotics and Polyene Acids from Marine Streptomyces fradiae PTZ0025
TLDR
The results indicated that fradimycin B (4) arrested the cell cycle at the G0/G1 phase and induced apoptosis and necrosis in colon cancer and glioma cells, demonstrating that the marine natural products 3–5 possessed potent antimicrobial and antitumor activities.
Antifungal activity of camptothecin, trifolin, and hyperoside isolated from Camptotheca acuminata.
TLDR
Bioassays showed that pure CPT and flavonoids isolated from Camptotheca effectively control fungal pathogens in vitro, including Alternaria alternata, Epicoccum nigrum, Pestalotia guepinii, Drechslera sp.
Flavanone glycosides from Miconia trailii.
TLDR
Assay-guided fractionation of the ethanol extract of the twigs and leaves of Miconia trailii yielded two new flavanone glycosides, matteucinol and farrerol, and the structures of 1-8 were elucidated by spectroscopic methods, including 2D NMR.
Camptothecin accumulation and variations in camptotheca.
TLDR
Because of higher CPT yield and desirable biological and ecological features, 'Hicksii' and 'Katie' should be considered the major management germplasm as CPT sources in the future.
Natural products inhibiting Candida albicans secreted aspartic proteases from Tovomita krukovii.
TLDR
Assay-guided fractionation of the ethanol extract of Tovomita krukovii resulted in the identification of four new xanthones and ten known compounds, which showed inhibitory effects against Candida albicans secreted aspartic proteases (SAP) and MRS.
Flavonoids, coumarins and triterpenes from the aerial parts of Cnidoscolus texanus.
TLDR
All flavonoids were found to be inactive against DNA topoisomerase I and their structures were determined by spectroscopic and chemical methods.
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