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Cancer esearch apeutics , Targets , and Chemical Biology 285 , a Novel C 2-Aryl-Substituted Pyrrolobenzodiazepine er Prodrug That Cross-links DNA and Exerts Highly R ent Antitumor Activity
SG2285 was defined as a highly active cytotoxic compound with antitumor properties desirable for further development and showed activity in several human xenograft models, including ovarian, non–small cell lung, prostate, pancreatic, and melanoma.