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Hierarchical B-splines have been widely used for shape modeling since their discovery by Forsey and Bartels. We present an application of this concept, in the form of free-form deformation, to image registration by matching two images at increasing levels of detail. Results using MRI brain data are presented that demonstrate high degrees of matching while(More)
The purpose of this study was to determine if in vivo high resolution 3D MRI and localized (1)H MR spectroscopy (MRS) can detect brain findings resembling Alzheimer's disease in a transgenic mouse model of Tau pathology. Seven double transgenic rTg4510 female mice and 7 age-matched wild-type (wt) female mice were evaluated at 5 months of age. To confirm the(More)
RATIONALE AND OBJECTIVES The purpose of this study was to test the hypothesis that distinct patterns of gray matter atrophy are responsible for unique interruptions of the naming process in Alzheimer's disease (AD) and frontotemporal dementia (FTD). MATERIALS AND METHODS Voxel-based morphometry (VBM) was performed to characterize at the voxel level the(More)
RATIONALE AND OBJECTIVES We study morphologic characteristics and age-related changes in patients with schizophrenia to investigate whether abnormal neurodevelopment and brain structure have a role in the pathophysiological course of this disease. MATERIALS AND METHODS Our data consist of a set of cranial magnetic resonance images of 46 patients with(More)
We present a new approach for quantifying the degradation of knee cartilage in the medial meniscal tear (MMT) model of osteoarthritis in the rat. A statistical strategy was used to guide the selection of a region of interest (ROI) from the images obtained from a pilot study. We hypothesize that this strategy can be used to localize a region of cartilage(More)
Deformation has received wide attention in the eld of Computer Graphics, Computer Vision and Image Processing. This paper describes a new method which is based on the concept of hierarchical BSplines. Compared with existing methods, our approach is adaptive in that it puts more e ort in complex regions which need more attention. It also provides an elegent(More)
RATIONALE AND OBJECTIVE Abnormal neurodevelopment may play a role in the pathophysiology of schizophrenia. We used deformation-based morphometry to examine voxel-wise age-related changes in patients with schizophrenia compared with healthy brains. MATERIALS AND METHODS We used a set of skull-stripped brains from an image database of cranial magnetic(More)
Coronary artery vibrometry is a new transthoracic Doppler ultrasound method for the detection of coronary artery stenosis. It detects audio-frequency vibrations generated by coronary artery luminal diameter reduction. We studied 31 patients with known or suspected stenosis using coronary artery vibrometry and quantitative coronary angiography and 83 normal(More)
The function of a brain region can be constrained by its anatomical connections. The Inferior Parietal Lobule (IPL) is a cortical region with marked functional heterogeneity, involved in visuospatial attention, memory, language and mathematical cognition. In this work three different variants of the normalized graph-cut clustering algorithm were applied to(More)
rTg4510 transgenic mouse model demonstrates features resembling Alzheimer's disease including neurofibrillary degeneration and progressive neuronal loss. We investigated the volumetric differences of brain structures between transgenic and wild-type mice using MR images of fourteen 5.5 month old female mice. Tensor-based morphometry and atlas-based(More)