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CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations.
  • X. Zheng, C. Xu, +10 authors M. Kahn
  • Biology, Medicine
  • The Journal of clinical investigation
  • 2 August 2010
Cerebral cavernous malformation is a common human vascular disease that arises due to loss-of-function mutations in genes encoding three intracellular adaptor proteins, cerebral cavernousExpand
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Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling.
Although platelets appear by embryonic day 10.5 in the developing mouse, an embryonic role for these cells has not been identified. The SYK-SLP-76 signaling pathway is required in blood cells toExpand
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Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns
The migration patterns of naive and activated T cells are associated with the expression of distinct sets of chemokine receptors, but the molecular basis for this regulation is unknown. Here weExpand
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Linking Receptor-mediated Endocytosis and Cell Signaling
Megalin, a member of the low density lipoprotein receptor gene family, is required for efficient protein absorption in the proximal tubule. Recent studies have shown that the low density lipoproteinExpand
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Corrigendum: Regulation of cardiovascular development and integrity by the heart of glass– cerebral cavernous malformation protein pathway
In the version of this article initially published, the plot labeled “Stress + Gal-1” duplicated the plot labeled “Control” for the IL-12p70 staining in Figure 2f. The corrected plots have now beenExpand
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Regulation of cardiovascular development and integrity by the Heart of Glass-Cerebral Cavernous Malformation pathway
Cerebral cavernous malformations (CCMs) are human vascular malformations caused by mutations in three genes of unknown function: KRIT1, CCM2 and PDCD10. Here we show that the heart of glass (HEG1)Expand
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Dynamic regulation of the cerebral cavernous malformation pathway controls vascular stability and growth.
Cardiovascular growth must balance stabilizing signals required to maintain endothelial connections and network integrity with destabilizing signals that enable individual endothelial cells toExpand
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Vectorial Acylation in Saccharomyces cerevisiae
In Saccharomyces cerevisiae Fat1p and fatty acyl-CoA synthetase (FACS) are hypothesized to couple import and activation of exogenous fatty acids by a process called vectorial acylation. MolecularExpand
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Blood flow reprograms lymphatic vessels to blood vessels.
Human vascular malformations cause disease as a result of changes in blood flow and vascular hemodynamic forces. Although the genetic mutations that underlie the formation of many human vascularExpand
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Fatty Acid Transport in Saccharomyces cerevisiae
The fatty acid transport protein Fat1p functions as a component of the long-chain fatty acid transport apparatus in the yeast Saccharomyces cerevisiae. Fat1p has significant homologies to theExpand
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