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We present two algorithms to solve the Group Lasso problem [33]. First, we propose a general version of the Block Coordinate Descent (BCD) algorithm for the Group Lasso that employs an efficient approach for optimizing each subproblem exactly. We show that it exhibits excellent performance when the groups are of moderate size. For groups of large size, we(More)
Holomycin and its derivatives belong to a class of broad-spectrum antibacterial natural products containing a rare dithiolopyrrolone heterobicyclic scaffold. The antibacterial mechanism of dithiolopyrrolone compounds has been attributed to the inhibition of bacterial RNA polymerase activities, although the exact mode of action has not been established in(More)
We consider a class of sparse learning problems in high dimensional feature space regularized by a structured sparsity-inducing norm that incorporates prior knowledge of the group structure of the features. Such problems often pose a considerable challenge to optimization algorithms due to the non-smoothness and non-separability of the regularization term.(More)
Cucumber has been widely studied as a model for floral sex determination. In this investigation, we performed genome-wide transcriptional profiling of apical tissue of a gynoecious mutant (Csg-G) and the monoecious wild-type (Csg-M) of cucumber in an attempt to isolate genes involved in sex determination, using the Solexa technology. The profiling analysis(More)
The 5′ fragment (1,678 bp) of the cucumber female-specific CsACS1G gene was transcriptionally fused to the green fluorescent protein (GFP) gene and GUS gene and functionally analyzed for important regulatory regions controlling gene expression in onion epidermal cells or stably transformed Arabidopsis plants. Progressive upstream deletion analyses of the(More)
The fluorinase is an enzyme that catalyses the combination of S-adenosyl-L-methionine (SAM) and a fluoride ion to generate 5'-fluorodeoxy adenosine (FDA) and L-methionine through a nucleophilic substitution reaction with a fluoride ion as the nucleophile. It is the only native fluorination enzyme that has been characterised. The fluorinase was isolated in(More)
Driven by increasing demand for the monitoring of industrial perfluorinated compounds (PFCs), the identification of novel fluorine containing compounds (FOCs) and the tracking of organofluorine drugs and their degradation products, there is a clear need for sensitive, fluorine-specific detection of unknown FOCs. Here we report the first ever direct(More)
Plant pathogens deliver effector proteins that alter host processes to create an environment conducive to colonization. Attention has focused on identifying the targets of effectors and how their manipulation facilitates disease. RXLR effector Pi04089 from the potato blight pathogen Phytophthora infestans accumulates in the host nucleus and enhances(More)
(Received 00 Month 200x; in final form 00 Month 200x) We consider the image denoising problem using total variation (TV) regularization. This problem can be computationally challenging to solve due to the non-differentiability and non-linearity of the regularization term. We propose an alternating direction augmented Lagrangian (ADAL) method, based on a new(More)