Learn More
The generation of large numbers of functional human hepatocytes for cell-based approaches to liver disease is an important and unmet goal. Direct reprogramming of fibroblasts to hepatic lineages could offer a solution to this problem but so far has only been achieved with mouse cells. Here, we generated human induced hepatocytes (hiHeps) from fibroblasts by(More)
The purpose of this study was to characterize the hepatobiliary disposition of timosaponin B2 (TB-2), a natural saponin. Although TB-2 has multiple pharmacologic activities, the mechanism of its hepatobiliary disposition has not been explored. Because the metabolism of TB-2 is limited and the accumulation of TB-2 in primary hepatocytes is highly temperature(More)
To improve the ecological conditions, the Chinese government adopted six large-scale ecological restoration programs including 'Three-North Shelterbelt Project', "Grain for Green Project" and "Beijing-Tianjin Sand Source Control Project". Meanwhile, these ecologically vulnerable areas have experienced frequent droughts. However, little attention has been(More)
Arid and semi-arid areas in North China are facing the challenge of a rising aeolian desertification risk (ADR) due to the intertwined effects of complex natural processes and intensified anthropogenic activities. An accurate quantitative assessment of the relationship between ADR and its determinants is beneficial for understanding the driving mechanisms(More)
Avionics systems play a significant role in civil aircraft, and its reliability is directly related to the flight safe. In this paper, integrated modular avionics (IMA), as the most advanced avionics systems, is analyzed. Via exploration of the interaction mechanism of IMA and real physical system, its property of cyber-physical systems (CPS) is determined.(More)
The purpose of this study was to characterize the hepatobiliary disposition of timosaponin B2 (TB-2), a natural saponin. Although TB-2 has multiple pharmacologic activities, the mechanism of its hepatobiliary disposition has not been explored. Because the metabolism of TB-2 is limited and the accumulation of TB-2 in primary hepatocytes is highly temperature(More)
This paper presents a control system using a T-S recurrent fuzzy network (TSRFN) to control the position of the mover of x-y table to track periodic reference trajectories. The two-axis motion control system is an x-y table composed of two permanent-magnet linear synchronous motors (PMLSM). The proposed TSRFN combines the merits of self-constructing fuzzy(More)
In this paper, the principle, structure of the Active Power Filter (APF) system and PWM control are all discussed, and based on the improved instantaneous reactive power theory, a kind of fast feasible algorithm for distortion currents detection, harmonic current suppression and reactive power compensation in shunt active power filter is put forward,(More)
Drug-induced cholestasis is a leading cause of drug withdrawal. However, the use of primary human hepatocytes (PHHs), the gold standard for predicting cholestasis in vitro, is limited by their high cost and batch-to-batch variability. Mature hepatocyte characteristics have been observed in human induced hepatocytes (hiHeps) derived from human fibroblast(More)