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Ginsenoside Rd attenuates beta-amyloid-induced tau phosphorylation by altering the functional balance of glycogen synthase kinase 3beta and protein phosphatase 2A

• Ling Li, Zhirong Liu, Juanfang Liu, Xuhui Tai, Guangyi Zhao
• Neurobiology of Disease
• 2013

Neurofibrillary tangles are aggregates of hyperphosphorylated tau that are one of the pathological hallmarks of Alzheimer's disease (AD). Tau phosphorylation is regulated by a balance of kinase and… (More)

ErbB2-intronic MicroRNA-4728: a novel tumor suppressor and antagonist of oncogenic MAPK signaling

• David C. Schmitt, Luciana Madeira da Silva, +10 authors Marcus C. B. Tan
• Cell Death and Disease
• 2015

Although the role of the ErbB2/HER2 oncogene in cancers has been extensively studied, how ErbB2 is regulated remains poorly understood. A novel microRNA, mir-4728, was recently found within an intron… (More)

Islet-1 expression and its colocalization with luteinising hormone, thyroid-stimulating hormone and oestrogen receptor alpha in the developing pituitary gland of the sheep foetus.

• Jin-hua Liu, Zhirong Liu, Seok Yi, Sheng Cui
• Journal of neuroendocrinology
• 2005

Islet-1 has been reported to be involved in pituitary development in the early stages of mouse embryogenesis. Oestrogen receptor (ER) and its expression may be involved in regulating pituitary… (More)

Rhein reverses the diabetic phenotype of mesangial cells over-expressing the glucose transporter (GLUT1) by inhibiting the hexosamine pathway.

• Junnian Zheng, J-M Zhu, Leixin Li, Zhirong Liu
• British journal of pharmacology
• 2008

BACKGROUND AND PURPOSE Rhein, an anthraquinone compound isolated from rhubarb, has been proved effective in treatment of experimental diabetic nephropathy (DN). To explore the mechanism of its… (More)

Far upstream element-binding protein 1 is a prognostic biomarker and promotes nasopharyngeal carcinoma progression

• Zhirong Liu, J-l Hu, +8 authors M Zeng
• Cell Death and Disease
• 2015

Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor with tremendous invasion and metastasis capacities, and it has a high incidence in southeast Asia and southern China. Previous studies… (More)

Inflammation Driven Activation of Wnt Pathway : A Potential Mechanism Responsible for Obesity-associated Colorectal Cancer

• Zhirong Liu, Yingke Yang
• 2016

Substantial evidence indicates that obesity, which has reached an epidemic proportion, is a robust risk factor for several types of cancer, particularly the colorectal cancer. As the worldwide… (More)

The impact of miR-26 b on retinal pigment epithelium cells in rhegmatogenous retinal detachment model

• Ruifan Zhang, Zhirong Liu, Binghong Chen, Junjun Zhang
• 2017

Rhegmatogenous retinal detachment (RRD) is a type of blind eye disease that seriously affects the physical and mental health. The early pathological changes are closely related to the migration of… (More)

Localisation and role of activin receptor-interacting protein 1 in mouse brain.

• Hongyu Liu, Yì N. Wáng, Jin Ge, Nan-lin Li, Xinyi Cui, Zhirong Liu
• Journal of neuroendocrinology
• 2013

Activin A, a stimulator of follicle-stimulating hormone secretion from the pituitary, acts as a neurotrophic and neuroprotective factor in the central nervous system. Activin receptor-interacting… (More)

Design, synthesis and biological evaluation of novel 1-phenyl phenanthridin-6(5H)-one derivatives as anti-tumor agents targeting TOPK.

• Quanyin Hu, Tianyun Gao, +5 authors Luo-Ting Yu
• European journal of medicinal chemistry
• 2018

T-lymphokine-activated killer cell-originated protein kinase (TOPK) is a serine-threonine mitogen-activated protein kinase that is highly expressed in many types of human cancer. Due to its important… (More)

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