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Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity
BackgroundObesity is a multifactorial disorder influenced by genetic and environmental factors. Animal models of obesity are required to help us understand the signaling pathways underlying thisExpand
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Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression
Triptolide, a diterpenoid triepoxide from the traditional Chinese medicinal herb Tripterygium wilfordii Hook. f., is a potential treatment for autoimmune diseases as well a possible anti-tumor agent.Expand
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Morphological characterization of single fan-shaped body neurons in Drosophila melanogaster
The fan-shaped body is the largest substructure of the central complex in Drosophila melanogaster. Two groups of large-field neurons that innervate the fan-shaped body, viz., F1 and F5 neurons, haveExpand
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Visual pattern memory requires foraging function in the central complex of Drosophila.
The role of the foraging (for) gene, which encodes a cyclic guanosine-3',5'-monophosphate (cGMP)-dependent protein kinase (PKG), in food-search behavior in Drosophila has been intensively studied.Expand
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STAT3 is involved in esophageal carcinogenesis through regulation of Oct-1.
The transcription factor signal transducer and activator of transcription 3 (STAT3) contributes to cell proliferation, apoptosis and motility in human cancer cells. We aim to elucidate the functionExpand
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Triptolide inhibits ovarian cancer cell invasion by repression of matrix metalloproteinase 7 and 19 and upregulation of E-cadherin
Triptolide, a compound extracted from the traditional Chinese medicine preparation of Tripterygium wilfordii Hook F., has been reported to have anti-inflammatory and anti-cancer activities. However,Expand
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ING5 inhibits cancer aggressiveness via preventing EMT and is a potential prognostic biomarker for lung cancer
The proteins of the Inhibitor of Growth (ING) candidate tumor suppressor family are involved in multiple cellular functions such as cell cycle regulation, apoptosis, and chromatin remodeling. ING5 isExpand
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A Compact and Low Power Consumption Optical Switch Based on Microrings
A compact optical switch array based on microrings using a high-index-contrast waveguide is presented with excellent performance. The 84 optical switch matrix occupies just 103mm and its extinctionExpand
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The effect of dexmedetomidine on inflammatory response of septic rats
BackgroundSome studies have demonstrated dexmedetomidine has anti-inflammatory effect on septic rats. However, the mechanism of how dexmedetomidine exerts these effects is still remained unknown.Expand
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Antioxidant effects of hydroxysafflor yellow A and acetyl-11-keto-β-boswellic acid in combination on isoproterenol-induced myocardial injury in rats
  • M. Chen, M. Wang, +8 authors A. Wen
  • Biology, Medicine
  • International journal of molecular medicine
  • 20 April 2016
Oxidative stress plays an important role in the initiation and development of myocardial injury (MI). The peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α)/nuclear factorExpand
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