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A new Self-Organizing Learning Array (SOLAR) system has been realized in software. SOLAR is capable of handling a wide variety of classification problems. It has a regular array structure with sparsely interconnected computing elements and local learning rules. Unlike artificial neural networks, this structure scales well to large systems capable of solving(More)
Summary form only given. We describe a new dynamically reconfigurable neuron hardware architecture based on the modified Xilinx Picoblaze microcontroller and self-organizing learning array (SOLAR) algorithm reported earlier. This architecture is aiming at using hundreds of traditional reconfigurable field programmable gate arrays (FPGAs) to build the SOLAR(More)
The global gene regulator Special AT-rich sequence-binding protein-1 (SATB1) has been reported to induce EMT-like changes and be associated with poor clinical outcome in several cancers. This study aims to evaluate whether SATB1 affects the biological behaviors of bladder transitional cell carcinoma (BTCC) and further elucidate if this effect works through(More)
The epithelial-mesenchymal transition (EMT) promotes cancer invasion and metastasis, however, the integrative mechanisms that coordinate the process are incompletely understood. In this study, we defined a pivotal functional role for the Forkhead transcription factor FOXQ1 in regulating EMT in bladder cancer. We initially investigated the expression of(More)
A DNA sequencing device which integrates transverse conducting electrodes for the measurement of electrode currents during DNA translocation through a nanopore has been nanofabricated and characterized. A focused electron beam (FEB) milling technique, capable of creating features on the order of 1 nm in diameter, was used to create the nanopore. The device(More)
The focus of this paper is a novel parallel and selforganizing neural network hardware architecture and its development. This architecture is based on self-organizing learning array (SOLAR) algorithm reported earlier. This hardware architecture is aimed at hundreds of tradit ional reconfigurable field programmable gate arrays (FPGAs). Its reconfigurability(More)
Hypoxia has been involved in the development of tumor by regulating the expression of invasiveness-associated genes. However, the specific function of hypoxia in cancer cell invasion is still unclear. The aim of the present study was to determine the role of hypoxia in invasion of prostate cancer PC3 cells and to investigate the underlying mechanisms. We(More)
Acknowledgements First of all, I want to thank my advisor – Dr. Starzyk, who recognized that the PicoBlaze microcontroller core is adaptable to neural network application at the very early stage after PicoBlaze was developed. And before then, I had been working on the SOLAR implementation using a kind of serial based processing in the hardware. This new(More)
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