Zhiming Zhao

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In e-Science, a Grid environment enables data and computing intensive tasks and provides a new supporting infrastructure for scientific experiments. Scientific workflow management systems (SWMS) hide the integration details among Grid resources and allow scientists to prototype an experimental computing system at a high level of abstraction. However, the(More)
Most of the existing scientific workflow management systems (SWMS) are driven by applications from specific domains and are developed in academic projects. It is challenging to introduce an existing SWMS to a new domain; not only the workflow model and description language do not easily fit in new problem domains, but also the unstable development state of(More)
Laparoscopic distal splenopancreatectomy (DSP) is an effective and safe surgical modality for treating benign and borderline distal pancreatic tumors, but rarely for pancreatic cancer. This study aimed to examine the feasibility, effectiveness, and safety of laparoscopic versus laparotomic DSP in pancreatic body-tail cancer (PBTC) patients. Thirty-four PBTC(More)
Peloruside A is a microtubule-stabilizing macrolide that binds to beta tubulin at a site distinct from the taxol site. The site was previously identified by H-D exchange mapping and molecular docking as a region close to the outer surface of the microtubule and confined in a cavity surrounded by a continuous loop of protein folded so as to center on Y340.(More)
Previous population investigations have suggested that the application of curcumin may be associated with decreased incidence and improved prognosis in certain types of cancer. Forkhead box O1 (FOXO1) has been implicated in the regulation of several biological processes, including stress resistance, metabolism, DNA repair, cell cycle and apoptosis. The aims(More)
This paper discusses the challenges that are imposed by Big Data Science on the modern and future Scientific Data Infrastructure (SDI). The paper refers to different scientific communities to define requirements on data management, access control and security. The paper introduces the Scientific Data Lifecycle Management (SDLM) model that includes all the(More)
SOX (high mobility group) genes play an important role in a number of developmental processes. Potential roles of SOXs have been demonstrated in various neoplastic tissues as tumor suppressors or promoters depending on tumor status and types. The aim of this study was to investigate the function role of SOXs in the human hepatocellular carcinoma (HCC). The(More)
This paper describes our approach to modeling computing infrastructures. Our main contribution is the Infrastructure and Network Description Language (INDL) ontology. The aim of INDL is to provide technology independent descriptions of computing infrastructures, including the physical resources as well as their network infrastructure. INDL also provides the(More)
In a problem solving environment (PSE), a scientific workflow management system (SWMS) provides a meta environment for managing activities and data in scientific experiments, for prototyping experimental computing systems and for orchestrating the runtime system behaviour. The realisation of a SWMS is often driven by domain specific applications and thus is(More)