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Resveratrol inhibits cell differentiation in 3T3-L1 adipocytes via activation of AMPK.
- Sifan Chen, Zi-lun Li, Wen-xue Li, Zhiming Shan, W. Zhu
- Chemistry, Medicine
- Canadian journal of physiology and pharmacology
- 21 October 2011
Resveratrol is capable of inhibiting lipogenesis and differentiation of 3T3-L1 adipocytes via activation of AMPK, suggesting its potential therapeutic application in the treatment or prevention of obesity. Expand
Long non-coding RNA Linc00675 suppresses cell proliferation and metastasis in colorectal cancer via acting on miR-942 and Wnt/β-catenin signaling.
- Zhiming Shan, N. An, Jielin Qin, Junmei Yang, Hong-qi Sun, Wei-Jei Yang
- Biology, Medicine
- Biomedicine & pharmacotherapy = Biomedecine…
- 1 May 2018
The findings suggested Linc00675 as a potential molecular marker and target for the diagnosis and treatment of CRC and enhanced the current understanding on the mechanisms of action of Linc00475 in CRC. Expand
Knockdown of lncRNA GHET1 inhibits osteosarcoma cells proliferation, invasion, migration and EMT in vitro and in vivo.
- Wei Yang, Zhiming Shan, +6 authors Z. Zhang
- Biology, Medicine
- Cancer biomarkers : section A of Disease markers
GHET1 was up-regulated in osteosarcoma tissues and cell lines, inhibited cell apoptosis, promoted cell proliferation, invasion and migration by affecting EMT in vitro, and was correlated with the tumor growth and metastasis in vivo. Expand
Age-Related Differences in the Association between Plasma High-Sensitivity C-Reactive Protein and Noncalcified or Mixed Coronary Atherosclerotic Plaques
The results suggest the potential significance of hsCRP-lowering regimens in older adults with NCP/MP and evaluate whether age has any impact on this association. Expand
Helveticoside Exhibited p53-dependent Anticancer Activity Against Colorectal Cancer.
Helveticoside might be a potential candidate for the development of novel chemotherapeutic agents for the treatment of colorectal cancer, while the potential toxic effects of helveticOSide may be worthy of further investigations. Expand
Expression and diagnostic value of miRNA in children with hand, foot and mouth disease of EV71 type
MiRNAs can be used as important indicators for diagnosing children with EV71 type HFMD, especially miR-148a,miR-628-3p, mi-R-143, mi R-324-3P, MiR-140-5p,MiR-455- 5p and mi-362- 3p, and ROC curve analysis showed that miRNA is abnormally expressed in children with EVs71 typeHFMD. Expand
Pioglitazone Ameliorates Lipid Metabolic Disorder in KKAy Mice
It is indicated that pio could regulate blood lipid level, reduce liver lipid deposition and enhance antioxidant capacity of mice with lipid metabolic disorder, which is possibly through increasing AMPKα phosphorylation. Expand
Effects of immunoglobulin combined with acupuncture therapy for children with hand-foot-and-mouth disease complicated with limb flaccid paralysis
Investigating the effects of immunoglobulin combined with acupuncture therapy on limb function and prognosis and rehabilitation in children with hand-foot-and-mouth disease and limb flaccid paralysis found its immunoregulatory effects of anti-GM1 antibody, IL-6,IL-8, TNF-α and other cytokines are the possible mechanisms. Expand