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Arginine biosynthesis in Corynebacterium glutamicum proceeds via a pathway that is controlled by arginine through feedback inhibition of NAGK, the enzyme that converts N-acetyl-l-glutamate (NAG) to N-acety-l-glutamy-l-phosphate. In this study, the gene argB encoding NAGK from C. glutamicum ATCC 13032 was site-directed, and the l-arginine-binding sites of(More)
Simian immunodeficiency virus (SIV) is closely related to human immunodeficiency virus (HIV), their matrix antigens (MAs) sharing some 50% sequence identity. MA is a component of Pr55Gag, the sole protein required for assembly of the virion shell. MA targets Pr55 to the plasma membrane, and facilitates incorporation of the virus envelope protein and(More)
and neural network approach to estimate the impact of groundwater abstractions on river 3 flows. Abstract 16 Evaluation of the impacts of groundwater abstractions on surface water systems is 17 a necessary task in integrated water resources management. A range of hydrological, 18 hydrogeological, and geomorphological factors influence the complex processes(More)
Haloarchaea is an important group of polyhydroxyalkanoate (PHA)-accumulating organisms. However, few promising haloarchaeal species for economical and efficient PHA production have been reported. Here, we first discovered that Halogranum amylolyticum TNN58 could efficiently accumulate poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) with a high(More)
  • N Forcadel, Z Rao, H Zidani
  • 2011
This paper deals with some optimal control problems governed by ordinary dierential equations with Radon measures as data and with pointwise state constraints. We study the properties of the value function and obtain its characterization by means of an auxiliary control problem of absolutely continuous trajectories. For this, we use some known techniques of(More)
It is now evident that a bidirectional communication network exists between the central nervous system (CNS) and immune system (IS). However, the way in which the IS passes inform to the brain is not quite clear.In the present study, one of the neural pathways involved in the cytokine-to-brain communication was investigated in the rat. This pathway starts(More)
Acetoin, a major extracellular catabolic product of Bacillus subtilis cultured on glucose, is widely used to add flavor to food and also serves as a precursor for chemical synthesis. The biosynthesis of acetoin from pyruvate requires the enzymes α-acetolactate synthase (ALS) and α-acetolactate decarboxylase (ALDC), both of which are encoded by the alsSD(More)
BACKGROUND Previously, a safe strain, Bacillus amyloliquefaciens B10-127 was identified as an excellent candidate for industrial-scale microbial fermentation of 2,3-butanediol (2,3-BD). However, B. amyloliquefaciens fermentation yields large quantities of acetoin, lactate and succinate as by-products, and the 2,3-BD yield remains prohibitively low for(More)
N-Acetyl-l-glutamate kinase (EC 2.7.2.8) is first committed in the specific l-arginine pathway of Corynebacterium sp. A limited increase of l-arginine production for the argB overexpression in the engineering C. creantum SYPA-CCB strain indicated that l-arginine feedback inhibition plays an influence on the l-arginine production. In this study, we have(More)