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Many wireless sensor network applications must resolve the inherent conflict between energy efficient communication and the need to achieve desired quality of service such as end-to-end communication delay. To address this challenge, we propose the Real-time Power-Aware Routing (RPAR) protocol, which achieves application-specified communication delays at(More)
Software defect prediction helps to optimize testing resources allocation by identifying defect-prone modules prior to testing. Most existing models build their prediction capability based on a set of historical data, presumably from the same or similar project settings as those under prediction. However, such historical data is not always available in(More)
In cancer treatment, apoptosis is a well-recognized cell death mechanism through which cytotoxic agents kill tumor cells. Here we report that dying tumor cells use the apoptotic process to generate potent growth-stimulating signals to stimulate the repopulation of tumors undergoing radiotherapy. Furthermore, activated caspase 3, a key executioner in(More)
Improving the quality of healthcare and the prospects of "aging in place" using wireless sensor technology requires solving difficult problems in scale, energy management, data access, security, and privacy. We present AlarmNet, a novel system for assisted living and residential monitoring that uses a two-way flow of data and analysis between the front- and(More)
The fundamental issue in cross project defect prediction is selecting the most appropriate training data for creating quality defect predictors. Another concern is whether historical data of open-source projects can be used to create quality predictors for proprietary projects from a practical point-of-view. Current studies have proposed statistical(More)
The molecular mechanisms involved in the derivation of induced pluripotent stem cells (iPSCs) from differentiated cells are poorly understood. Here we report that caspases 3 and 8, two proteases associated with apoptotic cell death, play critical roles in induction of iPSCs from human fibroblasts. Activation of caspases 3 and 8 occurs soon after(More)
Breast cancer is the most frequently diagnosed tumor type and the primary leading cause of cancer deaths in women worldwide and multidrug resistance is the major obstacle for breast cancer treatment improvement. Emerging evidence suggests that metformin, the most widely used antidiabetic drug, resensitizes and cooperates with some anticancer drugs to exert(More)
Despite the knowledge of many genetic alterations present in osteosarcoma, the complexity of this disease precludes placing its biology into a simple conceptual framework. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) plays important roles in downregulating T-cell activation, thereby attenuating anti-tumor responses and increasing cancer susceptibility.(More)
The role of miR-26a in cancer cells seemed controversial in previous studies. Until now, the role of miR-26a in gastric cancer remains undefined. In this study, we found that miR-26a was strongly downregulated in gastric cancer (GC) tissues and cell lines, and its expression levels were associated with lymph node metastasis and clinical stage, as well as(More)
BACKGROUND A fairly high prevalence of wound complications after open reduction and internal plate fixation (ORIF) of closed calcaneal fractures via the extensile lateral approach has been reported. The goal of this study was to analyze and identify independent risk factors for wound complications among closed calcaneal fractures undergoing ORIF. METHODS(More)