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OBJECTIVES Aromatase deficiency is a rare disorder resulting in estrogen insufficiency in humans. It has been reported in remarkably few men with loss-of-function mutations in the CYP19A1 gene encoding the aromatase, a cytochrome P450 enzyme that plays a crucial role in the biosynthesis of estrogens from androgens. We investigated a non-consanguineous(More)
Type 2 diabetes mellitus (T2DM) results from insulin resistance and β-cell dysfunction, in the setting of hyperglucagonemia. Glucagon is a 29 amino acid peptide hormone, which is secreted from pancreatic α cells: excessively high circulating levels of glucagon lead to excessive hepatic glucose output. We investigated if α-cell numbers increase in T2DM and(More)
Progression or recurrence due to resistance to aromatase inhibitors (AIs) is a significant clinical problem for a considerable number of patients with breast cancer. Programmed cell death 4 (PDCD4), a tumor suppressor protein, is targeted for degradation during tumor progression. In the current study, we aimed to examine PDCD4 expression and regulation in(More)
Resistance to endocrine therapies in hormone receptor (HR)-positive breast cancer is a significant clinical problem for a considerable number of patients. The oncogenic transcription factor c-MYC (hereafter referred to as MYC), which regulates glutamine metabolism in cancer cells, has been linked to endocrine resistance. We were interested in whether(More)
It has been proved that network evolving theory is efficient in network capacity evaluation. Network characteristics analysis is the foundation of network evolving research. For the purpose of satellite communication network capacity evaluation, the method for its network characteristics analysis is investigated in this text. With the definition of time(More)
Privacy protection is becoming more and more important due to the ubiquitous access to information. Distributed Hash Tables (DHTs) are widely used by peer-to-peer networks with more than one million concurrently active users. This paper proposes and designs a web based self-Destructing Instant Messenger (DIM) on eMule KAD DHT network in China without any(More)
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