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—We present a high-performance low-power design of linear array multipliers based on a combination of the following techniques: signal flow optimization in [3:2] adder array for partial product reduction, left-to-right leapfrog (LRLF) signal flow, and splitting of the reduction array into upper/lower parts. The resulting upper/lower LRLF (ULLRLF) multiplier(More)
In this paper we present a performance-driven mapping algorithm, PLAmap, for CPLD architectures which consist of a large number of PLA-style logic cells. The primary goal of our mapping algorithm is to minimize the depth of the mapped circuit. Meanwhile, we have successfully reduced the area of the mapped circuits by applying several heuristic techniques,(More)
This paper investigates the wire delay effect on the design of prefix adders when the technology moves from 250nm to 70nm. The simulation is based on parameters from NTRS'97 and uses an analytical wire delay model that considers the fanout effect and the distributive nature of wire capacitance and resistance. Simulation results show that wire delay exceeds(More)
A three-dimensional vector normalizer based on pipelined on-line arithmetic is presented. The clock period is kept small by the use of redundant adders and low-precision estimates. The throughput is greatly improved by unfolding and pipelining on-line units and the area is reduced due to left-to-right processing. Assuming the same area/delay metric, the(More)
In silico prediction of genomic long non-coding RNAs (lncRNAs) is prerequisite to the construction and elucidation of non-coding regulatory network. Chromatin modifications marked by chromatin regulators are important epigenetic features, which can be captured by prevailing high-throughput approaches such as ChIP sequencing. We demonstrate that the accuracy(More)
We propose a split array multiplier organized in a left-to-right leapfrog (LRLF) structure with reduced delay compared to conventional array multipliers. Moreover , the proposed design shows equivalent performance as tree multipliers for n ≤ 32. An efficient radix-4 recoding logic generates the partial products in a left-to-right order. The partial products(More)
MicroRNAs are small noncoding RNAs involved in various biological processes. We characterized the expression of miR-344-3p during mouse embryonic development. At E9.5–E10.5 and E15.5, in situ hybridization detected strong miR-344-3p signal in the central nervous system, including the cerebral cortex, hindbrain, cerebellum, thalamus, hindbrain, medulla(More)
Recent research has revealed that the maternal non-coding RNA genes (Gtl2, Rian and Mirg) from the Dlk1-Dio3 imprinted cluster are closely related to the full development potential of the induced pluripotent stem cells (iPSCs). Transcriptional silencing of these genes failed to generate all-iPSC mice, indicating their significant contribution to(More)