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Physapubescin B Exhibits Potent Activity against Human Prostate Cancer In Vitro and In Vivo.
The present data showed that a natural compound isolated from the plant Physalis pubescens L. (Solanaceae), physapubescin B, exhibited antitumor activity against prostate cancer in vitro and in vivo.Expand
Novel prenylated bichalcone and chalcone from Humulus lupulus and their quinone reductase induction activities.
A new prenylated chalcone xanthohumol M (1), a novel prenylated bichalcone humulusol (2) and six known chalcones (3-8) were found from Humulus lupulus. Their structures were determined byExpand
New analogues of brefeldin A from sediment-derived fungus Penicillium sp. DT-F29
Abstract Four new analogues of brefeldin A named 7, 7-dimethoxybrefeldin C (3), 6β-hydroxybrefeldin C (4), 4-epi-15-epi-brefeldin A (5), 4-epi-8α-hydroxy-15-epi-brefeldin C (6), together with fourExpand
Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution
Reprogramming of the NRPS/PKS assembly line is an attractive method for the production of new bioactive molecules. However, it is usually hampered by the loss of intimate domain/module interactionsExpand
Induction of quinone reductase (QR) by withanolides isolated from Physalis angulata L. var. villosa Bonati (Solanaceae)
In the present study, the EtOAc extract of the persistent calyx of Physalis angulata L. var. villosa Bonati (PA) was tested for its potential quinone reductase (QR) inducing activity with glutathioneExpand
Angucycline antibiotics and its derivatives from marine-derived actinomycete Streptomyces sp. A6H
Abstract Vineomycin A1 (1) and B2 (2) were isolated from the culture broth of marine actinomycete Streptomyces sp. A6H. Five hydrolysis products were obtained by rational hydrolysis and methanolysisExpand
Aminoacyl sulfonamide assembly in SB-203208 biosynthesis
Sulfonamide is present in many important drugs, due to its unique chemical and biological properties. In contrast, naturally occurring sulfonamides are rare, and their biosynthetic knowledge areExpand
Signaling natural products from human pathogenic bacteria.
Natural products from microorganisms are important small molecules that play roles in various biological processes like cellular growth, motility, nutrient acquisition, stress response, biofilmExpand
Interactions in the Competitive Coexistence Process of Streptomyces sp. and Escherichia coli
Competitive coexistence of different microorganism species is a fundamental ecological process in the evolution and maintenance of biodiversity. This work studied the interactions happened in theExpand