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Therapeutic effects of induced pluripotent stem cells in chimeric mice with β-thalassemia
Although β-thalassemia is one of the most common human genetic diseases, there is still no effective treatment other than bone marrow transplantation. Induced pluripotent stem cells have been… Expand
Claudin 6: a novel surface marker for characterizing mouse pluripotent stem cells
In utero transplantation of human hematopoietic stem/progenitor cells partially repairs injured liver in mice.
- H. Qian, J. Wang, +4 authors S. Huang
- Biology, Medicine
- International journal of molecular medicine
- 1 October 2006
The aim of this study is to establish a novel mouse model with high achievement and chimerism by in utero transplantation of human hematopoietic stem/progenitor cells and to explore the possibility… Expand
The mesenchymal stem cells derived from transgenic mice carrying human coagulation factor VIII can correct phenotype in hemophilia A mice.
- Q. Wang, Xiuli Gong, +4 authors Y. Zeng
- Biology, Medicine
- Journal of genetics and genomics = Yi chuan xue…
- 20 December 2013
Hemophilia A (HA) is an inherited X-linked recessive bleeding disorder caused by coagulant factor VIII (FVIII) deficiency. Previous studies showed that introduction of mesenchymal stem cells (MSCs)… Expand
[A study of the engraftment, expansion and differentiation of human hematopoietic stem cells in goats].
OBJECTIVE To establish a human/goat hematopoietic stem cell (HSC) xenogeneic transplant model and to probe the engraftment, expansion and differentiation of human HSC in vivo. METHODS Human HSCs… Expand
Identification and characterization of engrafted human cells in human/goat xenogeneic transplantation chimerism.
We have injected human CD34+lin- cells derived from cord blood (CB) into the goat fetuses via in utero at 45-55 days gestation under guidance of B-scan ultrasonograph. Sixty out of 68 fetuses… Expand
PhiC31 integrase induces efficient site-specific recombination in the Capra hircus genome.
Streptomyces phage φC31 integrase induces efficient site-specific recombination capable of integrating exogenous genes at pseudo attP sites in human, mouse, rat, rabbit, sheep, Drosophila, and bovine… Expand
[The expression of human specific proteins in liver tissue of chimeric goats engrafted with human hematopoitic stem cells].
OBJECTIVE To investigate the expression of human specific proteins in liver tissue obtained from goats engrafted with human hematopoietic stem cells (hHSC). METHODS hHSCs derived from cord blood… Expand
Treatment of β654‐thalassaemia by TALENs in a mouse model
This study explored whether TALENs‐mediated non‐homologous end joining (NHEJ) targeting the mutation site can correct the aberrant β‐globin RNA splicing, and ameliorate the β‐thalassaemia phenotype… Expand
A Herpes Simplex Virus Thymidine Kinase-Induced Mouse Model of Hepatocellular Carcinoma Associated with Up-Regulated Immune-Inflammatory-Related Signals
Inflammation and fibrosis in human liver are often precursors to hepatocellular carcinoma (HCC), yet none of them is easily modeled in animals. We previously generated transgenic mice with… Expand