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Therapeutic effects of induced pluripotent stem cells in chimeric mice with β-thalassemia
Although β-thalassemia is one of the most common human genetic diseases, there is still no effective treatment other than bone marrow transplantation. Induced pluripotent stem cells have beenExpand
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Claudin 6: a novel surface marker for characterizing mouse pluripotent stem cells
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In utero transplantation of human hematopoietic stem/progenitor cells partially repairs injured liver in mice.
  • H. Qian, J. Wang, +4 authors S. Huang
  • Biology, Medicine
  • International journal of molecular medicine
  • 1 October 2006
The aim of this study is to establish a novel mouse model with high achievement and chimerism by in utero transplantation of human hematopoietic stem/progenitor cells and to explore the possibilityExpand
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The mesenchymal stem cells derived from transgenic mice carrying human coagulation factor VIII can correct phenotype in hemophilia A mice.
  • Q. Wang, Xiuli Gong, +4 authors Y. Zeng
  • Biology, Medicine
  • Journal of genetics and genomics = Yi chuan xue…
  • 20 December 2013
Hemophilia A (HA) is an inherited X-linked recessive bleeding disorder caused by coagulant factor VIII (FVIII) deficiency. Previous studies showed that introduction of mesenchymal stem cells (MSCs)Expand
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[A study of the engraftment, expansion and differentiation of human hematopoietic stem cells in goats].
OBJECTIVE To establish a human/goat hematopoietic stem cell (HSC) xenogeneic transplant model and to probe the engraftment, expansion and differentiation of human HSC in vivo. METHODS Human HSCsExpand
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Identification and characterization of engrafted human cells in human/goat xenogeneic transplantation chimerism.
We have injected human CD34+lin- cells derived from cord blood (CB) into the goat fetuses via in utero at 45-55 days gestation under guidance of B-scan ultrasonograph. Sixty out of 68 fetusesExpand
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PhiC31 integrase induces efficient site-specific recombination in the Capra hircus genome.
Streptomyces phage φC31 integrase induces efficient site-specific recombination capable of integrating exogenous genes at pseudo attP sites in human, mouse, rat, rabbit, sheep, Drosophila, and bovineExpand
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[The expression of human specific proteins in liver tissue of chimeric goats engrafted with human hematopoitic stem cells].
OBJECTIVE To investigate the expression of human specific proteins in liver tissue obtained from goats engrafted with human hematopoietic stem cells (hHSC). METHODS hHSCs derived from cord bloodExpand
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Treatment of β654‐thalassaemia by TALENs in a mouse model
This study explored whether TALENs‐mediated non‐homologous end joining (NHEJ) targeting the mutation site can correct the aberrant β‐globin RNA splicing, and ameliorate the β‐thalassaemia phenotypeExpand
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A Herpes Simplex Virus Thymidine Kinase-Induced Mouse Model of Hepatocellular Carcinoma Associated with Up-Regulated Immune-Inflammatory-Related Signals
Inflammation and fibrosis in human liver are often precursors to hepatocellular carcinoma (HCC), yet none of them is easily modeled in animals. We previously generated transgenic mice withExpand
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