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BACKGROUND Brain retraction causes great distortion that limits the accuracy of an image-guided neurosurgery system that uses preoperative images. Therefore, brain retraction correction is an important intraoperative clinical application. METHODS We used a linear elastic biomechanical model, which deforms based on the eXtended Finite Element Method (XFEM)(More)
BACKGROUND The point-pair method is widely used to register the patient space and the image space in image-guided neuro surgery. In this kind of registration, the distribution of fiducial points has a great influence on the registration accuracy at the target point. METHODS In this paper we propose the idea of target registration accuracy contribution(More)
BACKGROUND Glycogen synthease kinase-3B is a key gene encoding a protein kinase which is abundant in brain, and is involved in signal transduction cascades of neuronal cell development and energy metabolism. Previous researches proposed GSK3B as a potential region for schizophrenia. METHOD To validate the susceptibility of GSK3B to major depressive(More)
As one of the pathogens of hospital-acquired infections, Acinetobacter baumannii poses great challenges to the public health. A. baumannii phage could be an effective way to fight multi-resistant A. baumannii. Here, we completed the whole genome sequencing of the complete genome of A. baumannii phage AB1, which consists of 45,159 bp and is a double-stranded(More)
This study examines the preventive and therapeutic effects of curcumin on brain edema after hypoxic-ischemic brain damage (HIBD) in a rat model. Male Sprague-Dawley rats were divided into four groups: a sham group (SH), a hypoxic-ischemic group (HI) without drug treatment, a hypoxic-ischemic group (CU) with curcumin injection, and a hypoxic-ischemic group(More)
In this study, we reported on the incorporation of a novel supramolecular hydrogel into agarose hydrogel to create a hybrid hydrogel. Both the supramolecular hydrogel and the hybrid hydrogel were characterized by scanning electron microscopy (SEM) and fluorescence microscopy, and their mechanical properties were evaluated by a compress assay. These results(More)
BACKGROUND Accurate patient to image registration is the core for successful image-guided neurosurgery. While skin adhesive markers (SMs) are widely used in point-matching registration, a proper implementation of anatomical landmarks (ALs) may overcome the inconvenience brought by the use of SMs. METHODS Using nine ALs, a set of three configurations of(More)
BACKGROUND Brain deformation plays an important role in causing inaccuracy in image-guided neurosurgery. Three types of approaches have been proposed to solve this problem: intra-operative imaging, deformation atlas and non-rigid registration. By comparing these approaches, we here show that the non-rigid registration approach, based on a linear elastic(More)
NVL (nuclear VCP (valosin containing protein)/p97-Like), a member of the AAA-ATPase (ATPases associated with various cellular activities) family, encodes a novel hTERT (human telomerase reverse transcriptase)-interacting protein NVL2 which is a telomerase component essential for holoenzyme assembly. Previous researches have reported the impacts of(More)
In image-guided neurosurgery, brain tissue displacement and deformation during neurosurgical procedures are a major source of error. In this paper, we implement and evaluate a linear-elastic-model-based framework for correction of brain shift using clinical data from five brain tumor patients. The framework uses a linear elastic model to simulate(More)