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BACKGROUND Glycogen synthease kinase-3B is a key gene encoding a protein kinase which is abundant in brain, and is involved in signal transduction cascades of neuronal cell development and energy metabolism. Previous researches proposed GSK3B as a potential region for schizophrenia. METHOD To validate the susceptibility of GSK3B to major depressive(More)
In image-guided neurosurgery, brain tissue displacement and deformation during neurosurgical procedures are a major source of error. In this paper, we implement and evaluate a linear-elastic-model-based framework for correction of brain shift using clinical data from five brain tumor patients. The framework uses a linear elastic model to simulate(More)
BACKGROUND Brain retraction causes great distortion that limits the accuracy of an image-guided neurosurgery system that uses preoperative images. Therefore, brain retraction correction is an important intraoperative clinical application. METHODS We used a linear elastic biomechanical model, which deforms based on the eXtended Finite Element Method (XFEM)(More)
BACKGROUND The point-pair method is widely used to register the patient space and the image space in image-guided neuro surgery. In this kind of registration, the distribution of fiducial points has a great influence on the registration accuracy at the target point. METHODS In this paper we propose the idea of target registration accuracy contribution(More)
This study examines the preventive and therapeutic effects of curcumin on brain edema after hypoxic-ischemic brain damage (HIBD) in a rat model. Male Sprague-Dawley rats were divided into four groups: a sham group (SH), a hypoxic-ischemic group (HI) without drug treatment, a hypoxic-ischemic group (CU) with curcumin injection, and a hypoxic-ischemic group(More)
As one of the pathogens of hospital-acquired infections, Acinetobacter baumannii poses great challenges to the public health. A. baumannii phage could be an effective way to fight multi-resistant A. baumannii. Here, we completed the whole genome sequencing of the complete genome of A. baumannii phage AB1, which consists of 45,159 bp and is a double-stranded(More)
BACKGROUND Brain deformation plays an important role in causing inaccuracy in image-guided neurosurgery. Three types of approaches have been proposed to solve this problem: intra-operative imaging, deformation atlas and non-rigid registration. By comparing these approaches, we here show that the non-rigid registration approach, based on a linear elastic(More)
In this study, we reported on the incorporation of a novel supramolecular hydrogel into agarose hydrogel to create a hybrid hydrogel. Both the supramolecular hydrogel and the hybrid hydrogel were characterized by scanning electron microscopy (SEM) and fluorescence microscopy, and their mechanical properties were evaluated by a compress assay. These results(More)
BACKGROUND Accurate patient to image registration is the core for successful image-guided neurosurgery. While skin adhesive markers (SMs) are widely used in point-matching registration, a proper implementation of anatomical landmarks (ALs) may overcome the inconvenience brought by the use of SMs. METHODS Using nine ALs, a set of three configurations of(More)
BACKGROUND Point-pair registration is widely used to register the patient and the image space in image-guided neurosurgery. The registration accuracy at the target point is influenced by the distribution of the fiducial points, and it is not always easy to achieve a good distribution in clinical practice. METHODS We propose one original configuration and(More)