Zhijian Song

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In image-guided neurosurgery, brain tissue displacement and deformation during neurosurgical procedures are a major source of error. In this paper, we implement and evaluate a linear-elastic-model-based framework for correction of brain shift using clinical data from five brain tumor patients. The framework uses a linear elastic model to simulate(More)
BACKGROUND Brain deformation plays an important role in causing inaccuracy in image-guided neurosurgery. Three types of approaches have been proposed to solve this problem: intra-operative imaging, deformation atlas and non-rigid registration. By comparing these approaches, we here show that the non-rigid registration approach, based on a linear elastic(More)
As a major extracellular matrix component, ITIHs played an important role in inflammation and carcinogenesis. Several genome-wide association studies have reported that some positive signals which were derived from the tight linkage disequilibrium region on chromosome 3p21 were associated with both schizophrenia and bipolar disorders in the Caucasian(More)
Accurate pre-operative assessment of tumor grade is important for the selection of appropriate treatment strategies. The aim of this study was to retrospectively evaluate whether the fiber density index (FDi) and fractional anisotropy (FA) via diffusion tensor MRI (DTI) could assist with pre-operative diagnosis of glioma grade. A total of 31 patients who(More)
BACKGROUND/AIMS Augmented reality (AR) technology solves the problem of view switching in traditional image-guided neurosurgery systems by integrating computer-generated objects into the actual scene. However, the state-of-the-art AR solution using head-mounted displays has not been widely accepted in clinical applications because it causes some(More)
Refractive errors and high myopia are the most common ocular disorders, and both of them are leading causes of blindness in the world. Recently, genetic association studies in European and Japanese population identified that common genetic variations located in 15q14 and 15q25 were associated with high myopia. To validate whether the same variations(More)
BACKGROUND Brain retraction causes great distortion that limits the accuracy of an image-guided neurosurgery system that uses preoperative images. Therefore, brain retraction correction is an important intraoperative clinical application. METHODS We used a linear elastic biomechanical model, which deforms based on the eXtended Finite Element Method (XFEM)(More)
OBJECTIVE CT-based spinal navigation systems have widespread clinical applications, and spatial registration is a major source of the application error for these systems. However, the feedback that a surgeon may receive from the system, i.e., the surface registration error (SRE), is misleading, and it is still unclear how to achieve an optimal registration.(More)