Zhijian Huang

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The transport cycle in the glutamate transporter (GlT) is catalyzed by the cotransport of three Na(+) ions. However, the positions of only two of these ions (Na1 and Na2 sites) along with the substrate have been captured in the crystal structures reported for both the outward-facing and the inward-facing states of Glt(ph). Characterizing the third ion(More)
Glutamate transporters (GluTs) are the primary regulators of extracellular concentration of the neurotransmitter glutamate in the central nervous system. In this study, we have investigated the dynamics and coupling of the substrate and Na(+) binding sites, and the mechanism of cotransport of Na(+) ions, using molecular dynamics simulations of a(More)
In this paper we present an extensive computational experience with several Newton-like methods, namely Newton’s method, the ABS Huang method, the ABS row update method and six Quasi-Newton methods. The methods are first tested on 31 families of problems with dimensionsn=10, 50, 100 and two starting points. Newton’s method appears to be the best in terms of(More)
Membrane transporters rely on highly coordinated structural transitions between major conformational states for their function, to prevent simultaneous access of the substrate binding site to both sides of the membrane--a mode of operation known as the alternating access model. Although this mechanism successfully accounts for the efficient exchange of the(More)
When using Genetic Algorithm (GA) to optimize the feature space of pattern classification problems, the performance improved is not only determined by the data set used, but also depend on the classifier. This work compares the improvements acquired by GA optimized feature transformations on several simple classifiers. Some traditional feature(More)
Computational modeling and molecular simulation techniques have become an integral part of modern molecular research. Various areas of molecular sciences continue to benefit from, indeed rely on, the unparalleled spatial and temporal resolutions offered by these technologies, to provide a more complete picture of the molecular problems at hand. Because of(More)
Conformational changes of proteins are involved in all aspects of protein function in biology. Almost all classes of proteins respond to changes in their environment, ligand binding, and interaction with other proteins and regulatory agents through undergoing conformational changes of various degrees and magnitudes. Membrane channels and transporters are(More)
Membrane transporters facilitate active transport of their specific substrates, often against their electrochemical gradients across the membrane, through coupling the process to various sources of cellular energy, for example, ATP binding and hydrolysis in primary transporters, and pre-established electrochemical gradient of molecular species other than(More)
Advanced Persistent Threat (APT) poses a serious threat to cyber security, and its unique high unpredictability, deep concealment and grave harmfulness make the traditional network monitoring technology facing unprecedented challenges in the background of massive and complicated network traffic. This paper aimed for the urgent demand of APT network(More)
Observation of autosoliton propagation in a dispersion-managed optical transmission system controlled by in-line nonlinear fiber loop switches is reported for what is believed to be the first time. The system is based on a strong dispersion map with large amplifier spacing. Operation at transmission rates of 10 and 40 Gbits/s is demonstrated.