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Previous investigations of the neural code for complex object shape have focused on two-dimensional pattern representation. This may be the primary mode for object vision given its simplicity and direct relation to the retinal image. In contrast, three-dimensional shape representation requires higher-dimensional coding derived from extensive computation. We(More)
A small size broadband microstrip patch antenna for 14.0GHz radar application with multiple substrates had been fabricated using LTCC technology. A combination of a relatively low dielectric constant LTCC substrate and a relatively high dielectric constant LTCC substrate had been incorporated to reduce the effect of trade-off relationship between antenna(More)
BACKGROUND Avian influenza A virus H5N1 has caused widespread infections that have resulted in severe disease or death in poultry and wild birds as well as human beings. This virus has the potential to emerge as a pandemic threat and H5N1 vaccines are being developed in many countries. Our aim was to assess the safety and immunogenicity of an inactivated(More)
Previous studies have indicated that interleukin-1 beta (IL-1 beta) is involved not only in immune modulation, but also in the modulation of pain in both the peripheral and central nervous systems. The current study investigated the expression of IL-1 beta in the brain of rats with spared nerve injury (SNI), using immunohistochemical technique. The results(More)
The pro-inflammatory cytokine tumor necrosis factor-α (TNF-α) is associated with the generation of inflammatory and neuropathic pain. The current study aims to investigate the expression of TNF-α in the brain of rats with spared nerve injury (SNI), a neuropathic pain model with the lesion of common peroneal and tibial nerves. Two weeks following SNI, the(More)
Inflammation and apoptosis play an important role in cerebral ischemic pathogenesis and may represent a target for treatment. Silibinin has been proved to elicit a variety of biological effects through its anti-inflammatory and anti-apoptotic properties in hepatotoxic, cancer and carcinogenic events. Whether this protective effect applies to ischemic injury(More)
Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly activated by mutation in non-small cell lung cancer. The mechanism of this oncogenic activation is not completely understood, but in contrast to that of the wild-type EGFR, it is proposed to be independent of kinase domain dimerization. Mechanistic studies on EGFR have(More)
BACKGROUND X-linked adrenoleukodystrophy (X-ALD) is an inherited neurodegenerative disorder caused by mutations in the ABCD1 gene. Approximately 20% of X-ALD female carriers may develop neurological symptoms. Skewed X chromosome inactivation (XCI) has been proposed to influence the manifestation of symptoms in X-ALD carriers, but data remain conflicting so(More)
Domoic acid (DA) causes neurological effects in multiple species upon exposure, including status epilepticus in pregnant sea lions and an epileptic disease state that commonly develops in juveniles. This study aims to define brain toxicokinetic parameters in the pregnant rat in the larger context of maternal-fetal toxin transfer. Specifically,(More)