Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
- A. Degterev, Zhihong Huang, Junying Yuan
- BiologyNature Chemical Biology
- 1 July 2005
It is demonstrated that necroptosis contributes to delayed mouse ischemic brain injury in vivo through a mechanism distinct from that of apoptosis and offers a new therapeutic target for stroke with an extended window for neuroprotection.
Hypertension in mice lacking the gene for endothelial nitric oxide synthase
- Paul L Huang, Zhihong Huang, M. Fishman
- Biology, MedicineNature
- 21 September 1995
Responses to NOS blockade in the mutant mice suggest that non-endothelial isoforms of NOS may be involved in maintaining blood pressure, and eNOS mediates basal vasodilation.
Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia.
- A. Schinzel, O. Takeuchi, S. Korsmeyer
- BiologyProceedings of the National Academy of Sciences…
- 23 August 2005
CypD-deficient mice displayed a dramatic reduction in brain infarct size after acute middle cerebral artery occlusion and reperfusion, strongly supporting an essential role for CypD in an ischemic injury model in which calcium overload and oxidative stress have been implicated.
Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model
- H. Bolay, U. Reuter, A. Dunn, Zhihong Huang, D. Boas, M. Moskowitz
- Psychology, BiologyNature Network Boston
- 1 February 2002
This work establishes a link between migraine aura and headache by demonstrating that cortical spreading depression activates trigeminovascular afferents and evokes a series of cortical meningeal and brainstem events consistent with the development of headache.
A2A Adenosine Receptor Deficiency Attenuates Brain Injury Induced by Transient Focal Ischemia in Mice
- Jiang-fan Chen, Zhihong Huang, M. Schwarzschild
- Biology, MedicineJournal of Neuroscience
- 1 November 1999
It is suggested that A2A receptors play a prominent role in the development of ischemic injury within brain and demonstrate the potential for anatomical and functional neuroprotection against stroke by A 2A receptor antagonists.
Dual Role of Caspase-11 in Mediating Activation of Caspase-1 and Caspase-3 under Pathological Conditions
- S. Kang, Suyue Wang, Junying Yuan
- Biology, ChemistryJournal of Cell Biology
- 1 May 2000
It is demonstrated that caspase-11–deficient mice have a reduced number of apoptotic cells and a defect in casp enzyme-3 activation after middle cerebral artery occlusion (MCAO), a mouse model of stroke, and that Recombinant procaspases can autoprocess itself in vitro.
Neuronal Nitric Oxide Synthase Activation and Peroxynitrite Formation in Ischemic Stroke Linked to Neural Damage
- M. Eliasson, Zhihong Huang, M. Moskowitz
- BiologyJournal of Neuroscience
- 15 July 1999
These findings provide a cellular localization for nNOS activation in association with ischemic stroke and establish that NO is not likely a direct neurotoxin, whereas its conversion to peroxynitrite is associated with cell death.
Inhibition of Rho Kinase (ROCK) Leads to Increased Cerebral Blood Flow and Stroke Protection
- Y. Rikitake, Hyung-Hwan Kim, J. Liao
- Medicine, BiologyStroke
- 1 October 2005
Findings indicate that the neuroprotective effect of ROCK inhibition is mediated by endothelium-derived NO and suggest that ROCK may be an important therapeutic target for ischemic stroke.
Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2
- J. Bonventre, Zhihong Huang, A. Sapirstein
- Biology, MedicineNature
- 11 December 1997
After transient middle cerebral artery occlusion, cPLA2−/− mice had smaller infarcts and developed less brain oedema and fewer neurological deficits, indicating importance in the pathophysiology of neuronal death after transient focal cerebral ischaemia.
Laser Speckle Flowmetry for the Study of Cerebrovascular Physiology in Normal and Ischemic Mouse Cortex
- C. Ayata, A. Dunn, Yasemin Gursoy-Özdemir, Zhihong Huang, D. Boas, M. Moskowitz
- MedicineJournal of Cerebral Blood Flow and Metabolism
- 1 July 2004
LSF has distinct advantages over LDF for CBF monitoring because of high spatial resolution, and is useful to assess noninvasively two-dimensional cerebral blood flow with high temporal and spatial resolution.
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