Src family kinase inhibitor PP2 efficiently inhibits cervical cancer cell proliferation through down-regulating phospho-Src-Y416 and phospho-EGFR-Y1173
- L. Kong, Zhihong Deng, Haiying Shen, Yuxiang Zhang
- BiologyMolecular and Cellular Biochemistry
- 1 February 2011
The results indicate that Src pathway and EGFR pathway play different roles in the proliferation of cervical cancer cells and PP2 efficiently reduces cervical cancer cell proliferation by reduction of both Src and EG FR activity.
Down-regulation of phospho-non-receptor Src tyrosine kinases contributes to growth inhibition of cervical cancer cells
- L. Kong, Zhihong Deng, Yan-zhi Zhao, Ya-min Wang, F. Sarkar, Yuxiang Zhang
- Biology, MedicineMedical Oncology
- 1 December 2011
Immunohistochemical and confocal microscope studies suggested that pSrcY416 is overexpressed in HeLa and SiHa cells, as well as in the clinical cervical cancer tissues, compared to the normal cervical tissues, and nrTKs could be a novel therapeutic targets for the treatment of cervical cancer.